Table 2.
Univariate analysis of the relationship between Helicobacter pylori virulence genotypes and clinical outcome according to country, from patients presenting peptic ulcer disease or non-ulcer dyspepsia.
| Prevalence (%) PUD vs NUD p-value†; OR [95%CI] |
|||||
| homB | homA | cagA | vacA s1 | babA | |
| Portugal 50 PUD; 50 NUD |
59.6 vs 56.0 N.S. |
40.4 vs 44.0 N.S. |
72.3 vs 40.0 0.002; 1.88 [1.26–2.81] |
63.8 vs 44.0 N.S. |
48.9 vs 32.0 N.S. |
| France 27 PUD; 6 NUD |
74.1 vs 28.6 N.S. |
37.0 vs 71.4 N.S. |
85.2 vs 60.0 N.S. |
85.2 vs 80.0 N.S. |
80.0 vs 50.0 N.S. |
| Sweden 12 PUD; 10 NUD |
41.7 vs 30.0 N.S. |
58.3 vs 70 N.S. |
83.3 vs 70.0 N.S. |
66.7 vs 70.0 N.S. |
83.3 vs 40.0 N.S. |
| Germany 9 PUD; 10 NUD |
55.6 vs 60.0 N.S. |
44.4 vs 40.0 N.S. |
100 vs 80 N.S. |
100 vs 80.0 N.S. |
77.8 vs 60.0 N.S. |
| USA 10 PUD; 13 NUD |
40.0 vs 33.3 N.S. |
60.0 vs 66.7 N.S. |
60.0 vs 91.7 N.S. |
70.0 vs 91.7 N.S. |
100 vs 91.7 N.S. |
| Brazil 10 PUD; 12 NUD |
70.0 vs 27.3 N.S. |
30.0 vs 72.7 N.S. |
60 vs 18.2 N.S. |
50.0 vs 27.3 N.S. |
100 vs 100 N.S. |
| Colombia 9 PUD; 9 NUD |
77.8 vs 60.0 N.S. |
33.3 vs 50.0 N.S. |
55.6 vs 80 N.S. |
66.7 vs 70.0 N.S. |
100 vs 70.0 N.S. |
| Japan 42 PUD; 28 NUD |
95.5 vs 92.9 N.S. |
4.7 vs 3.6 N.S. |
100 vs 100 N.A |
100 vs 100 N.A |
100 vs 100 N.A |
| South Korea 28 PUD; 37 NUD |
83.3 vs 73.7 N.S. |
16.7 vs 26.3 N.S. |
100 vs 100 N.A |
100 vs 100 N.A |
100 vs 100 N.A |
Among the 415 isolates initially included, 43 (36 PUD strains and 7 NUD) harbored both homA and homB genes and were excluded from further analyses. These 49 isolates comprised all the 11 isolates from Burkina Faso.
† p-value was determined by the Fisher's Exact Test.
OR, odds ratio.
N.S., not significant.
N.A, not applicable.
PUD, peptic ulcer disease
NUD, non-ulcer dyspepsia