Table 1.

Ventilation at rest in adult wild-type (+/+) and homozygous (−/−) mice for deletions of intron 1 (i1RR knockout), of exons 5 and 6 (del E5+6 knockout) of the AChE gene, or of the anchor molecule PRiMA.

	i1RR +/+ (n = 6)	i1RR −/− (n=6)	P	% difference
V̇E (mL/(g min−1))	2.01 ± 0.1	2.65 ± 0.14	<0.01	+32.5
VT (µL/g)	10.9 ± 0.3	13.3 ± 0.7	<0.02	+22
fR (breaths/min)	185 ± 11	204 ± 19	NS	+10
Ti (ms)	105 ±7	89 ±5	NS	−15
TE (ms)	232 ± 18	222 ± 30	NS	−4
TI/TTOT (%)	31.5 ± 1.10	30.0 ± 2.68	NS	−5
VT/TI (µL/(g s−1))	106 ± 5.9	153 ± 13.2	<0.01	+44
Weight (g)	19.4 ± 0.67	14.5 ± 1.07	<0.01	−25
Temperature (°C)	37.4 ± 0.21	38.1 ± 0.26	NS	+2
	Del E5+6 +/+ (n = 7)	Del E5+6 −/− (n=7)
V̇E (mL/(g min−1))	1.81 ± 0.11	2.57 ± 0.12	<0.001	+42
VT (µL/g)	10.9 ± 0.42	13.8 ± 0.60	<0.01	+27
fR (breaths/min)	167 ± 11	188 ±9	NS	+12
Ti (ms)	109 ±8	80 ± 1	<0.01	−27
TE (ms)	266 ± 21	244 ± 15	NS	−8
TI/TTOT (%)	29.7 ± 1.6	26.8 ±2	NS	−10
VT/TI (µL/(g s−1))	104 ± 9.5	166 ± 13	<0.01	+59
Weight (g)	23.9 ± 1.0	17.6 ± 1.7	<0.01	−26.5
Temperature (°C)	37.8 ± 0.2	37.8 ± 0.1	NS	0
	PRiMA +/+ (n = 6)	PRiMA −/− (n=8)
V̇E (mL/(g min−1))	1.62 ± 0.16	1.48 ± 0.10	NS	−9
VT (µL/g)	10.4 ± 0.58	10.4 ± 1.02	NS	0
fR (breaths/min)	154 ±8	148 ±8	NS	−4
Ti (ms)	113 ±4	118 ± 9.0	NS	+4.5
TE (ms)	293 ± 20	307 ± 23.0	NS	+5
TI/TTOT (%)	28.8 ± 1.5	28.2 ± 1.6	NS	−2
VT/TI (µL/(g s−1))	94 ± 7.4	93 ± 13.2	NS	−1
Weight (g)	28.5 ± 2.3	30.1 ± 3.5	NS	+5.5
Temperature (°C)	37.2 ± 0.2	37.1 ± 0.2	NS	0
	AChE +/+ (n = 9)	AChE −/− (n=9)
V̇E (mL/(g min−1))	1.34 ± 0.12	2.28 ± 0.19	<0.001	+70
VT (µL/g)	9.6 ± 1.1	18.8 ± 1.60	<0.001	+96
fR (breaths/min)	144 ±7	130 ± 12	NS	−10
Ti (ms)	130 ±5	74 ± 4	<0.001	−43
TE (ms)	301 ± 20	448 ± 47	<0.02	+49
TI/TTOT (%)	30.9 ± 1.4	15.5 ± 1.6	<0.001	−50
VT/TI (µL/(g s−1))	76 ± 10	264 ± 31	<0.001	+247
Weight (g)	24.9 ± 0.83	16.3 ± 1.10	<0.001	−34.5
Temperature (°C)	36.7 ± 0.4	36.6 ± 0.27	NS	0

Values for mice with deletion of the AChE gene (Boudinot et al., 2004) are presented for reference.