Figure 6.

Cannabinoid CB₂ receptors are expressed by astrocytes, as revealed by colocalization with GFAP (upper panels), and reactive microglia, as revealed by colocalization with OX-42 (bottom panels). Upper panels: 100x magnification photographs of the striatum of lesioned animals. CB₂ receptors are located in cell bodies and proximal portions of cellular processes of astrocytes (marked with arrows). Bottom panels: 100x magnification photographs of the striatum of lesioned animals. CB₂ receptors are abundantly expressed in areas of intense microgliosis, although not all reactive microglial cells are CB₂ receptor-positive (marked with arrows). Additional non-microglial cells (mainly astrocytes, as previously shown in upper panels) are also CB₂-positive.