Table 4.
Top 30 Overrepresented GO Categories: BD Meta-Analysis Data Set
| GO Category | Type | Total Genes in Category | No. of Genes on List | Expected No. of Genes on List | p Value | Expected Hits per Study | Function |
|---|---|---|---|---|---|---|---|
| GO05179 | FUNCTION | 75 | 10 | 2.83 | 0.0000 | 0.57 | hormone activity |
| GO03700 | FUNCTION | 692 | 88 | 64.03 | 0.0000 | 0.57 | transcription factor activity |
| GO16236 | PROCESS | 7 | 3 | 0.24 | 0.0000 | 0.57 | macroautophagy |
| GO30212 | PROCESS | 6 | 5 | 0.43 | 0.0000 | 0.57 | hyaluronan metabolic process |
| GO00045 | PROCESS | 6 | 3 | 0.24 | 0.0000 | 0.57 | autophagic vacuole formation |
| GO03677 | FUNCTION | 1776 | 189 | 148.04 | 0.0002 | 0.9 | DNA binding |
| GO03676 | FUNCTION | 2550 | 259 | 215.15 | 0.0002 | 0.9 | nucleic acid binding |
| GO33077 | PROCESS | 6 | 3 | 0.25 | 0.0002 | 0.9 | T cell differentiation in the thymus |
| GO08380 | PROCESS | 181 | 23 | 10.74 | 0.0002 | 0.9 | RNA splicing |
| GO06323 | PROCESS | 75 | 12 | 3.68 | 0.0002 | 0.9 | DNA packaging |
| GO42301 | FUNCTION | 6 | 3 | 0.3 | 0.0002 | 0.9 | phosphate binding |
| GO06465 | PROCESS | 7 | 4 | 0.6 | 0.0002 | 0.9 | signal peptide processing |
| GO04867 | FUNCTION | 81 | 17 | 7.24 | 0.0004 | 1.26 | serine-type endopeptidase inhibitor activity |
| GO05102 | FUNCTION | 572 | 74 | 53.92 | 0.0004 | 1.26 | receptor binding |
| GO33151 | PROCESS | 5 | 3 | 0.26 | 0.0004 | 1.26 | V(D)J recombination |
| GO06623 | PROCESS | 3 | 2 | 0.21 | 0.0004 | 1.26 | protein targeting to vacuole |
| GO07034 | PROCESS | 18 | 7 | 1.95 | 0.0006 | 1.63 | vacuolar transport |
| GO00398 | PROCESS | 57 | 9 | 2.58 | 0.0008 | 2.01 | nuclear mRNA splicing, via spliceosome |
| GO00377 | PROCESS | 57 | 9 | 2.58 | 0.0008 | 2.01 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO00375 | PROCESS | 57 | 9 | 2.58 | 0.0008 | 2.01 | RNA splicing, via transesterification reactions |
| GO30528 | FUNCTION | 1066 | 128 | 101.76 | 0.0010 | 2.41 | transcription regulator activity |
| GO18345 | PROCESS | 4 | 3 | 0.3 | 0.0010 | 2.41 | protein palmitoylation |
| GO05634 | CELLULAR | 3617 | 372 | 328.82 | 0.0014 | 3.22 | nucleus |
| GO44249 | PROCESS | 602 | 70 | 51.32 | 0.0014 | 3.22 | cellular biosynthetic process |
| GO02521 | PROCESS | 51 | 10 | 4.06 | 0.0016 | 3.6 | leukocyte differentiation |
| GO30098 | PROCESS | 39 | 9 | 3.2 | 0.0018 | 4 | lymphocyte differentiation |
| GO05853 | CELLULAR | 5 | 2 | 0.07 | 0.0018 | 4 | eukaryotic translation elongation factor 1 complex |
| GO04364 | FUNCTION | 16 | 4 | 0.5 | 0.0018 | 4 | glutathione transferase activity |
| GO01958 | PROCESS | 3 | 3 | 0.46 | 0.0024 | 5.22 | endochondral ossification |
| GO07076 | PROCESS | 15 | 5 | 1.12 | 0.0028 | 6.02 | mitotic chromosome condensation |
List of 30 most significant GO categories for BD in the BD meta-analysis data set (cutoff for significant SNPs: p < 0.01). Genotyped and imputed SNPs used, with SNPs assigned to genes if they lie within that gene. The type of category and the expected number of categories with a category-specific overrepresentation p value at least as significant as that observed in the absence of any true overrepresentation are also shown.