Table II.
Clinical characteristics of the novel BCR-ABL-like subtype of ALL
| Clinical feature | Group | Unit | COALL cohort | DCOG cohort | ||||
|---|---|---|---|---|---|---|---|---|
| BCR-ABL-like | B-other1 | P-value4 | BCR-ABL-like | B-other1 | P-value4 | |||
| N=30 | N=119 | N=14 | N=77 | |||||
| Age at diagnosis | all patients | median (years) | 6.0 | 4.5 | 0.14 | 7.4 | 4.0 | 0.15 |
| <10 years | %(N) | 67% (20) | 78% (93) | 71% (10) | 88% (68) | |||
| ≥10 years | %(N) | 33% (10) | 22% (36) | 0.23 | 29% (4) | 12% (9) | 0.11 | |
| WBC at diagnosis | all patients | median (/nl) | 46.3 | 21.0 | 0.004 | 49.0 | 15.6 | 0.010 |
| <25/nl | %(N) | 33% (10) | 55% (65) | 29% (4) | 61% (47) | |||
| ≥25/nl | %(N) | 67% (20) | 45% (54) | 0.043 | 71% (10) | 39% (30) | 0.039 | |
| Risk group | LR | %(N) | 17% (5) | 44% (52) | - | - | ||
| HR | %(N) | 83% (25) | 56% (67) | 0.006 | - | - | ||
| SR | %(N) | - | - | 7% (1) | 26% (20) | |||
| MR | %(N) | - | - | 50% (7) | 61% (47) | |||
| HR | %(N) | - | - | 36% (5) | 9% (7) | 0.0325 | ||
| NEL/NIT2 | %(N) | - | - | 7% (1) | 4% (3) | |||
| Follow-up | CCR3 | %(N) | 63% (19) | 84% (100) | 50% (7) | 78% (60) | ||
| relapse | %(N) | 37% (11) | 16% (19) | 0.020 | 50% (7) | 22% (17) | 0.046 | |
1
precursor B-ALL cases excluding BCR-ABL-like and BCR-ABL-positive cases
2
NEL/NIT; not eligible/not in treatment protocol
3
CCR, continuous complete remission
4
Mann-Whitney U test for continuous variables and Chi-square for categorical variables
5
NEL/NIT category excluded