Table 3.
ABCB1 diplogtype groupings.
| Diplotype | Chromosome 1 |
Chromosome 2 |
|||||
|---|---|---|---|---|---|---|---|
| 1236C>T | 2677G>T/A | 3435C>T | 1236C>T | 2677G>T/A | 3435C>T | Frequency (%) | |
| Diplotype 1 | C | G | C | C | G | C | 15 (16.9) |
| Diplotype 2 | C | G | C | * | * | * | 26 (29.2) |
| Diplotype 3 | C | G | C | T | T | T | 21 (23.6) |
| Diplotype 4 | T | T | T | * | * | * | 16 (18) |
| Diplotype 5 | T | T | T | T | T | T | 11 (12.4) |
| Diplotype 6 | – | G | C | – | G | C | 19 (21.3) |
| Diplotype 7 | – | G | C | – | † | † | 18 (20.2) |
| Diplotype 8 | – | G | C | – | T | T | 27 (30.3) |
| Diplotype 9 | – | T | T | – | † | † | 12 (13.5) |
| Diplotype 10 | – | T | T | – | T | T | 13 (14.6) |
*
Diplotype were grouped based on the previous approaches to reflect whether or not individual carried a fully wild-type or fully variant halplotype (21, 25).
†
represent any combination of alleles that is not mutually exclusive with another diplotype consisting of all 1236-2677-3435 SNPs and 2677-3435 SNPs, respectively. 1236 SNP was not considered in calculation of the diplotypes 6-10.