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. Author manuscript; available in PMC: 2009 Jul 8.
Published in final edited form as: Lancet Neurol. 2009 Jan;8(1):110–124. doi: 10.1016/S1474-4422(08)70294-1

Figure 7. Likely sequence of events leading to the major neuropathological sequelae observed with germinal matrix haemorrhage (GMH)–intraventricular haemorrhage (IVH) with periventricular haemorrhagic infarction (PHI).

Figure 7

The primary destructive events involve the GMH-IVH with PHI and the associated destruction of premyelinating oligodendrocytes (pre-OLs) and axons. The secondary consequence of the former is hypomyelination, and that of the latter is impaired thalamic and cortical development. In addition, because of destruction of the dorsal subventricular zone (SVZ) and ventral germinative epithelium of the ganglionic eminence (GE), impaired proliferation and late migration of GABAergic interneurons to upper cortical layers and the thalamus could contribute to defective cortical and thalamic development.