Figure 5.

Change in FEV₁ from pre-dose value in first 60 minutes after dosing on day 85 for IB/FEN delivered by Respimat^® (two doses) and by pMDI compared with placebo devices in COPD patients. Reprinted from Kilfeather SA, Ponitz HH, Beck E, et al. 2004. Improved delivery of ipratropium bromide/fenoterol from Respimat^® Soft Mist™ Inhaler in patients with COPD. Respir Med, 98:387–97. Copyright © 2004, with permission from Elsevier.

Abbreviations: MDI, metered dose inhaler; SMI, Soft Mist™ inhaler.