Table 1.
Demographic and baseline characteristics by baseline FEV1 severity
| Total population (n=1465) | FEV1 <50% predicted (n=949) | FEV1 ≥50% predicted (n=513) | |
|---|---|---|---|
| Male | 1060 (72%) | 714 (75%) | 343 (67%) |
| Age | 63 (9) | 64 (8) | 62 (9) |
| ICS at screen | 630 (51%) | 525 (55%) | 226 (44%) |
| LABAs at screen | 506 (41%) | 413 (44%) | 178 (35%) |
| Current smokers | 746 (51%) | 456 (48%) | 288 (56%) |
| Pack-years | 43 (22) | 43 (22) | 41 (22) |
| SGRQ total score | 48.2 (16.3) | 50.7 (15.8) | 43.5 (16.3) |
| Pre-bronchodilator FEV1 (L) | 1.27 (0.48) | 1.03 (0.31) | 1.71 (0.40) |
| Pre-bronchodilator FVC (L) | 2.47 (0.79) | 2.23 (0.71) | 2.90 (0.76) |
| % predicted FEV1 | 44.6 (13.9) | 36.1 (8.1) | 60.3 (6.9) |
| % reversibility in predicted FEV1 | 3.8 (4.4) | 4.0 (4.4) | 3.5 (4.3) |
NOTES: Data are number (%) or mean (SD) unless otherwise indicated. Three patients have missing baseline FEV1, so are not included in either subgroup.
Abbreviations: FVC, forced vital capacity; ICS, inhaled corticosteroids; LABAs, long-acting β2-agonists; SGRQ, St George’s Respiratory Questionnaire.