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. Author manuscript; available in PMC: 2009 Jul 8.
Published in final edited form as: IET Syst Biol. 2008 Sep;2(5):273–284. doi: 10.1049/iet-syb:20080116

Figure 1.

Figure 1

Input (HER phosphorylation) and output (Erk and Akt phosphorylation) time-series for the studied HME cell lines: A) Parental, B) 17L C) 24H and D) A11H. In each of these panels, Iexp refers to the receptor phosphorylation levels measured in the ELISA experiments for EGFR (solid line) and HER2 (dashed line) - the inputs to the phosphorylation-based model. Itotal refers to the total abundances of phosphorylated EGFR (solid) and HER2 (dashed) - the inputs to the total-based model. Idimer refers to the abundances of EGFR-EGFR (solid), EGFR-HER2 (dashed) and HER2-HER2 (dash-dotted) dimers - the inputs to the dimer-based model. Oexp refers to the system outputs: Erk (solid) and Akt (dashed). Iexp, Idimer and Itotal are each expressed in units of 1000s of molecules. The outputs are expressed in a normalized form. Note that some of the subplots in panel D have different y-scales compared to the corresponding subplots in panels A-C.