Table 1.
| Table 1a. Risk of AOM Complicating URI by Pathogenic Bacteria Colonized in the Nasopharynx at the Time of URI. | |||||
|---|---|---|---|---|---|
| NP Bacterial colonization (n=646a) |
AOM Incidence (%) |
OR, (95% CI) |
p-value | Adjusted OR,b (95% CI) |
p-value |
| No Bacteria (102) | 10 | REF | REF | REF | REF |
| Sp only (55) | 29 | 3.7 (1.6–9.0) | <0.01 | 3.8 (1.6–9.1) | <0.01 |
| Hi only (54) | 43 | 6.8 (2.9–15.9) | <0.01 | 6.7 (2.8–15.9) | <0.01 |
| Mc only (148) | 32 | 4.4 (2.1–9.2) | <0.01 | 4.2 (2.0–8.8) | <0.01 |
| Sp, Hi (18) | 50 | 9.2 (3.0–28.5) | <0.01 | 8.0 (2.1–30.0) | <0.01 |
| Sp, Mc (136) | 41 | 6.4 (3.1–13.4) | <0.01 | 5.7 (2.7–12.2) | <0.01 |
| Hi, Mc (45) | 51 | 9.6 (4.0–23.0) | <0.01 | 8.4 (3.2–21.5) | <0.01 |
| Sp, Hi, Mc (88) | 51 | 9.6 (4.4–20.9) | <0.01 | 15.3 (6.0–39.6) | <0.01 |
| Table 1b. Risk of AOM Complicating URI by Pathogenic Bacteria Colonized in the Nasopharynx at the Time of URI (excluding NP swabs collected at the time of AOM diagnosis). | |||||
|---|---|---|---|---|---|
| NP Bacterial colonization (541a) |
AOM incidence % |
OR, (95% CI) |
p-value | Adjusted OR,b (95% CI) |
p-value |
| No Bacteria (97) | 5 | REF | REF | REF | REF |
| Sp only (46) | 15 | 3.3 (0.99 – 11.0) | 0.04 | 3.5 (1.0 – 12.3) | 0.05 |
| Hi only (39) | 21 | 4.7 (1.4–15.6) | <0.01 | 5.2 (1.5–17.9) | <0.01 |
| Mc only (119) | 16 | 3.5 (1.2–9.7) | <0.01 | 3.7 (1.3–10.3) | 0.01 |
| Sp, Hi (11) | 18 | 4.1 (0.7 – 24.2) | 0.09 | 10.5 (1.1 – 101.8) | 0.04 |
| Sp, Mc (96) | 17 | 3.7 (1.3–10.5) | 0.01 | 3.7 (1.2–10.9) | 0.02 |
| Hi, Mc (26) | 15 | 3.3 (0.8–13.4) | 0.07 | 3.6 (0.8–16.3) | 0.1 |
| Sp, Hi, Mc (53) | 19 | 4.3 (1.4–13.3) | <0.01 | 7.5 (1.9–30.4) | <0.01 |
63 cultures that grew other bacteria including Staphylococcus aureus, Group A beta helmolytic Streptococcus, Group B beta hemolytic Streptococcus, Diptheriods, and Bacillus species are not included. Multiple bacteria listed are from the same sample. In 168 (68%) cases AOM was diagnosed at the time of NP swab collection.
OR adjusted for breastfeeding, smoking and day care exposure
Abbreviations: OR: odd ratio, REF: reference rate for odds ratio, Sp: Streptococcus pneumoniae, Hi: Haemophilus influenzae, Mc: Moraxella catarrhalis.
57 cultures that grew other bacteria including Staphylococcus aureus, Group A beta helmolytic Streptococcus, Diptheriods, and Bacillus species are not included. Multiple bacteria listed are from the same sample.
OR adjusted for breastfeeding, smoking and day care exposure
Abbreviations: OR: odd ratio, REF: reference rate for odds ratio, Sp: Streptococcus pneumoniae, Hi: Haemophilus influenzae, Mc: Moraxella catarrhalis.