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Proposed aromatic interaction motif. Side (top panel) and cytosolic (bottom panel) view of the ab initio model of LdNT1.1 (helices shown in tan) showing a cluster of three aromatic residues (Phe48, Trp75, and Phe436) that may interact to close an extracellular gate formed by TM1, TM2, and TM7. These three amino acids are indicated by stick and space-filling representations of the side chains.
