Individual subject patterns of inflammatory mediators during the smoking cessation program. Individual subject patterns of serum inflammatory mediators (associated with increased risk of CVD) during the smoking cessation process (visits 1 through 4) are shown for TNF (A), sTNFR-I (B), sTNFR-II (C), sVCAM-1 (D), IL-6 (E), and CRP (F). Open symbols denote mediator values for individual subjects (taking NRT + bupropion) whose inflammatory mediators declined over the smoking cessation program; closed symbols denote values for individual subjects where no changes in inflammatory mediator levels were observed.