Figure 2.
Treatment with laminin-derived peptides enhanced granulation when applied topically. Wounds were harvested at day 4. Wounds were treated with 2.5 to 50 µg in 50 µl. A13 treatments showed significant increases in granulation. At 2.5 µg, A13 showed a 6% (± 2.6) increase. Granulation increased at the 5 µg dose to 11% (±3). At higher doses of A13, a decrease was observed. At 25 µg, an 11% (±3) decrease in granulation was observed. The effect at the 50 µg dose was not statistically significant. C16 treatments resulted in 9% (±3) increase in granulation at 2.5 µg and 5 µg doses. A slightly lower increase of to 8% (±3) occurred at the 25 µg dose. Measurements are expressed as the mean % increase ± SEM. (*p≤0.002, **p≤0.02).