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. 2009 Jul 17;4(7):e6250. doi: 10.1371/journal.pone.0006250

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Bergholdt et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Protein-protein interactions in this network originates from predicted genetic interactions between the HLA-region on chromosome 6 (BAT1, ITPR3, RPS18 and TUBB) and chromosomal regions on chromosome 2 (around D2S177, HNRPL), chromosome 13 (D13S170, LMO7), chromosome 4 (D4S403, WDR1) and chromosome 16 (D16S287, RPS15A), respectively. The ELF5 gene is positioned on chromosome 11. Red arrows and corresponding plots refer to four genes that were demonstrated significantly down-regulated in human pancreatic islets upon cytokine-stimulation. In the plots nodes to the left represent expression levels for all nine donors in un-stimulated condition, whereas nodes to the right represent cytokine-stimulated expression levels.