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. 2009 Jul 17;4(7):e6294. doi: 10.1371/journal.pone.0006294

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Buchhave et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The figure shows the mean baseline and follow-up levels of CSF tau (panel A) and CSF Aβ42 (panel B) in healthy controls (HC), that were followed for 4 years (y), and in two cohorts of patients with Alzheimer's disease (AD) that were followed for one or two years, respectively. Error bars represent standard errors of the mean. The figure illustrates that differences between controls and AD patients by far surpass the within-group differences over time.