Table 1. Demographic characteristics of the AD patients and the age-matched controls at baseline and follow-up.
| Controls, n = 34 | 1-year AD cohort, n = 100 | 2-year AD cohort, n = 45 | |
| Age, years | 72±8.3 | 74±7.2 | 73±7.1 |
| Sex, M/F | 10/24 | 36/64 | 22/23 |
| APOE ε4 carrier, % | 26.5 | 67.7a | 75.6a |
| Follow-up time, y | 3.8±0.1 | 1.2±0.2 | 2.1±0.2 |
| MMSE, baseline (0–30 p) | 29.3±1.0 | 21.8±4.8a | 23.4±4.4a |
| MMSE, follow-up (0–30 p) | 28.7±1.2 | 20.4±5.6 | 20.2±6.9 |
Values are means±SD, except as noted otherwise.
a
p<0.001 vs Controls.
Abbreviations: 1-year AD cohort, AD patients with approximately one year between baseline and follow-up lumbar puncture; 2-year AD cohort, AD patients with approximately two years between baseline and follow-up lumbar puncture; Controls, healthy controls followed for 4 years; APOE ε4 carrier, at least one apolipoprotein E ε4 allele; MMSE, Mini-Mental State Examination.