Table 2. Key parameters in the epidemiological model.
Parameter | Estimate [Range in Sensitivity Analyses] |
Duration of infectiousness [23] | |
Typical case | 4 weeks |
Mild case | 3 weeks |
Asymptomatic case | 1 week |
Vaccine efficacy [10], [26] | |
After the first dose | 46.0% [0.0–88.2] |
After the second dose | 79.6% [24.6–94.5] |
After the third dose | 91.7% [74.5–97.3] |
After the fourth dose | 96.4% [86.4–99.0] |
After booster dose | 92.0% [32.0–99.0] |
Vaccine coverage | |
Childhood | Between 80% & 96% depending on age |
Adolescent | 75% |
Cocoon strategy | 65% [35%–95%] |
Routine adult vaccination | 40% [20%–60%] |
% of cases resulting from exposure to household contacts [27] , [28] | |
0–1 months | 48.1% [38.0, 58.2] |
2–3 months | 48.1% [38.0, 58.2] |
4–5 months | 48.1% [38.0, 58.2] |
6–12 months | 33.6% [25.6–41.6] |
13–18 months | 39.2% [25.5, 52.9] |
19–24 months | 41.7% [25.0, 58.3] |
2 years | 38.2% [23.5, 55.9] |
3 years | 41.5% [26.8, 56.1] |
4 years | 40.5% [26.2, 54.8] |
5 years | 23.6% [12.7, 34.5] |
Case fatality rates [29] | |
Typical cases | |
<1 year | 0.69% [0.52–0.86] |
1–9 years | 0.05% [0.04–0.06] |
10–17 years | 0% [0–0] |
18+ years | 0.03% [0.02–0.04] |
Mild cases | |
<1 year | 0.0% [0–0] |
1–9 years | 0.0% [0–0] |
10–17 years | 0.0% [0–0] |
18+ years | 0.0% [0–0] |
Rates of long term sequelae [29] | |
Typical cases | |
<1 year | 0.06% [0.05–0.08] |
1–9 years | 0.02% [0.01–0.02] |
10–17 years | 0.02% [0.01–0.02] |
18+ years | 0.02% [0.01–0.02] |
Mild cases | |
<1 year | 0.0% [0–0] |
1–9 years | 0.0% [0–0] |
10–17 years | 0.0% [0–0] |
18+ years | 0.0% [0–0] |