Figure 6. The association of prenatal exposure to malaria with acquisition of MSP1₄₂ and AMA1, and EBA-175 specific IgG responses in all children.

There were no differences between the proportion of children with antibody responses to MSP1₄₂ and AMA1 between the three groups beginning at 12 months of age as determined by a generalized estimating equation described in Figure 5 (exposed not sensitized group compared to exposed sensitized group: relative risk for MSP1₄₂, 1.05 [0.88–1.17], p = 0.457; for AMA1, 0.87 [0.74–1.11], p = 0.251), but a significant reduction for EBA-175–specific IgG, 0.41 [0.28–0.97], p = 0.03. Similar effect sizes were observed for exposed not sensitized children compared to not exposed children (unpublished data).