Table 5. CTLA4 genotype frequencies in TB cases stratified for the sizes of opacities in chest radiographs1.
Opacity Score | ||||||||
CTLA4 SNP | 0 | 1 | 2 | 3 | OR2 | 95%CI3 | P | Pcor 4 |
N | 17 | 349 | 1075 | 364 | ||||
−1765 AA | 0.0% | 30.1% | 29.6% | 26.4% | 1 | |||
AG | 64.7% | 44.7% | 49.3% | 51.4% | 1.09 | 0.9–1.4 | 0.498 | |
GG | 35.3% | 25.2% | 21.1% | 22.2% | 0.85 | 0.6–1.1 | 0.268 | |
N | 17 | 347 | 1074 | 363 | ||||
−1722 AA | 82.3% | 74.3% | 72.6% | 71.1% | 1 | |||
AG | 17.6% | 23.1% | 24.9% | 27.3% | 1.14 | 0.9–1.5 | 0.277 | |
GG | 0.0% | 2.6% | 2.4% | 1.6% | 1.09 | 0.5–2.3 | 0.822 | |
N | 17 | 342 | 1056 | 357 | ||||
−1661 AA | 52.9% | 73.1% | 71.9% | 68.9% | 1 | |||
AG | 47.1% | 24.0% | 25.9% | 27.4% | 1.05 | 0.8–1.3 | 0.692 | |
GG | 0.0% | 2.9% | 2.3% | 3.6% | 1.25 | 0.6–2.4 | 0.505 | |
N | 3 | 183 | 565 | 183 | ||||
−443 AA | 100.0% | 68.3% | 69.2% | 67.8% | 1 | |||
AT | 0.0% | 29.0% | 27.1% | 30.6% | 1.03 | 0.8–1.4 | 0.838 | |
TT | 0.0% | 2.7% | 3.7% | 1.6% | 0.83 | 0.4–1.7 | 0.618 | |
N | 17 | 338 | 1040 | 347 | ||||
+49 GG | 52.9% | 45.9% | 37.7% | 40.6% | 1 | |||
GA | 47.1% | 42.6% | 47.9% | 46.1% | 1.17 | 0.9–1.5 | 0.180 | |
GG | 0.0% | 11.5% | 14.4% | 13.3% | 1.38 | 1.0–1.9 | 0.061 | |
N | 3 | 180 | 545 | 175 | ||||
+923 CC | 66.7% | 51.7% | 55.2% | 56.0% | 1 | |||
CT | 33.3% | 41.1% | 38.6% | 34.3% | 0.84 | 0.7–2.3 | 0.289 | |
TT | 0.0% | 7.2% | 6.2% | 9.7% | 1.33 | 0.6–1.1 | 0.199 | |
N | 17 | 350 | 1079 | 364 | ||||
+6230 GG | 47.1% | 63.1% | 65.6% | 63.2% | 1 | |||
GA | 47.1% | 29.4% | 30.8% | 35.2% | 1.06 | 0.8–1.3 | 0.602 | |
AA | 5.9% | 7.4% | 3.6% | 1.6% | 0.39 | 0.2–0.7 | 0.0004 | 0.005 |
Analysed by ordinal logistic regression.
Odds ratio.
Confidence interval.
Bonferroni-corrected by the factor of 14 for testing 7 SNPs not in strong linkage disequilibria and two disease phenotypes.