Table 2.
Main respiratory functional parameters at baseline and after additional doses of salbutamol
| STEP 1 Baseline | STEP 2 200 μg | STEP 3 600 μg | STEP 4 1000 μg | |
|---|---|---|---|---|
| Subjects, no. | 21 | 21 | 21 | 17 |
| FEV1, L | 1.14 ± 0.40 | 1.26 ± 0.43c | 1.32 ± 0.45c | 1.42 ± 0.50c |
| FVC, L | 2.55 ± 0.88 | 2.83 ± 0.93c | 2.97 ± 0.97c | 3.02 ± 1.03c |
| V˙max30, L/s | 0.24 ± 0.15 | 0.29 ± 0.21 | 0.35 ± 0.27c | 0.36 ± 0.24c |
| V˙part30, L/s | 0.42 ± 0.21 | 0.51 ± 0.24 | 0.54 ± 0.29c | 0.57 ± 0.28c |
| VC, L | 2.65 ± 0.85 | 2.98 ± 0.89c | 3.14 ± 0.97c | 3.36 ± 1.08c |
| FRC, L | 5.28 ± 1.42 | 5.02 ± 1.40c | 4.85 ± 1.34c | 4.72±1.30c |
| RV, L | 4.22 ± 1.35 | 3.96 ± 1.31c | 3.82 ± 1.32c | 3.59 ± 1.35c |
| TLC, L | 6.92 ± 1.54 | 6.94 ± 1.57 | 6.95 ± 1.57 | 6.97 ± 1.50 |
| HbCOa, % | 2.3 ± 0.6 | 3.3 ± 0.6c | 4.3 ± 0.6c | 5.2 ± 0.7c |
| VA, L | 4.93 ± 1.00 | 5.17 ± 1.06 | 5.05 ± 1.03 | 5.15 ± 1.07 |
| DLCO, ml/mmHg/min/L | 14.35 ± 5.07 | 15.12 ± 4.81 | 15.72 ± 4.95 | 16.41 ± 5.02b |
| DLCO/V A, ml/mmHg/min/L | 3.03 ± 1.20 | 3.07 ± 1.17 | 3.21 ± 1.08 | 3.23 ± 1.06 |
a
Note: HbCO, carboxyhemoglobin measured in 10 patients;
b
p < 0.05;
c
p < 0.01 or less versus baseline; Data are means ± SD.
Abbreviations: DLCO, carbon monoxide diffusing capacity; FEV1, forced expiratory volume in one second; FRC, functional residual capacity; FVC, forced vital capacity; RV, residual volume; SD, standard deviation; TLC, total lung capacity; V˙max30 and V˙part30, maximal and partial forced expiratory flows at 30% control FVC; VA, alveolar volume; VC, vital capacity.