Table 4.
Summary and analysis of change in diagnosis by individual predictor variables for asthma, COPD, mixed disease, and other disorders
| Asthma (n=18931) | No change in diagnosis (n [%]=8643 [45.7]) | Change in diagnosis (n [%]=10288 [54.3]) | Odds ratio calculation | Odds ratio (95% CI) | ||
|---|---|---|---|---|---|---|
| N | % | n | % | |||
| Gendera | ||||||
| Male | 3421 | 40.7 | 4983 | 59.3 | Females to males | 0.70 (0.66, 0.74); p<0.001 |
| Female | 5211 | 49.6 | 5298 | 50.4 | ||
| Mean age, years (±SD) | 62.0 (±11.4) | 65.6 (±10.6) | Per 10 years | 1.35 (1.31, 1.38); p<0.001 | ||
| Smoking2 | ||||||
| Smokers | 2396 | 39.5 | 3663 | 60.5 | ||
| Ex-smokers | 3740 | 43.0 | 4952 | 57.0 | Ex-smokers to smokers | 0.87 (0.81, 0.93); p<0.001 |
| Non-smokers | 2018 | 61.1 | 1287 | 38.9 | Non-smokers to smokers | 0.42 (0.38, 0.46); p<0.001 |
| FEV1b, mean (±SD) | 1.92 (±0.73) | 1.40 (±0.59) | Per litre | 0.29 (0.28, 0.31); p<0.001 | ||
| FEV1/FVCc, mean (±SD) | 72.8 (±37.4) | 60.4 (±14.7) | Per 10% | 0.52 (0.50, 0.54); p<0.001 | ||
| COPD (n=14572) | No change in diagnosis (n [%]=12544 [86.1]) | Change in diagnosis (n [%]=2028 [13.9]) | Odds ratio calculation | Odds ratio (95% CI) | ||
| N | % | n | % | |||
| Gendera | ||||||
| Male | 7575 | 88.5 | 982 | 11.5 | Females to males | 1.63 (1.48, 1.79); p<0.001 |
| Female | 4967 | 82.6 | 1046 | 17.4 | ||
| Mean age, years (±SD) | 69.9 (±9.1) | 68.4 (±10.0) | Per 10 years | 0.84 (0.80, 0.89); p<0.001 | ||
| Smokingb | ||||||
| Smokers | 4505 | 88.5 | 585 | 11.5 | ||
| Ex-smokers | 6529 | 86.8 | 994 | 13.2 | Ex-smokers to smokers | 1.17 (1.05, 1.31); p<0.001 |
| Non-smokers | 861 | 70.2 | 366 | 29.8 | Non-smokers to smokers | 3.27 (2.82, 3.80); p<0.001 |
| FEV1c, mean (±SD) | 1.20 (±0.54) | 1.61 (±0.69) | Per litre | 2.89 (2.67, 3.14); p<0.001 | ||
| FEV1/FVCd, mean (±SD) | 55.9 (±17.6) | 67.6 (±15.3) | Per 10% | 1.54 (1.46, 1.62); p<0.001 | ||
| Mixed disease (n=3979) | No change in diagnosis (n [%]=2168 [54.5]) | Change in diagnosis (n [%]=1811 [45.4]) | Odds ratio calculation | Odds ratio (95% CI) | ||
| N | % | n | % | |||
| Gendera | ||||||
| Males | 1098 | 54.2 | 929 | 45.8 | Females to males | 0.97 (0.86, 1.10); p=0.66b |
| Females | 1069 | 54.8 | 880 | 45.2 | ||
| Mean age, years (±SD) | 67.2 (±10.2) | 67.7 (±9.9) | Per 10 years | 1.06 (1.00, 1.13); p=0.07 | ||
| Smokingc | ||||||
| Smokers | 669 | 52.7 | 601 | 47.3 | p=0.129 | |
| Ex-smokers | 1084 | 54.3 | 913 | 45.7 | Ex-smokers to smokers | |
| Non-smokers | 290 | 58.0 | 210 | 42.0 | Non-smokers to smokers | |
| FEV1d, mean (±SD) | 1.39 (±0.59) | 1.35 (±0.62) | Per litre | 0.90 (0.80, 1.01); p=0.07 | ||
| FEV1/FVCe, mean (±SD) | 60.8 (±15.4) | 60.3 (±15.1) | Per 10% | 0.98 (0.91, 1.06); p=0.59 | ||
| Other (n=3979) | No change in diagnosis (n [%]=2168 [54.5]) | Change in diagnosis (n [%]=1811 [45.4]) | Odds ratio calculation | Odds ratio (95% CI) | ||
| N | % | n | % | |||
| Gendera | ||||||
| Male | 1080 | 34.4 | 2060 | 65.6 | Females to males | 0.80 (0.71, 0.89); p<0.001 |
| Female | 1023 | 39.7 | 1551 | 60.3 | ||
| Mean age, years (±SD) | 66.0 (±10.9) | 68.1 (±10.4) | Per 10 years | 1.21 (1.15, 1.27); p<0.001 | ||
| Smokingb | ||||||
| Smokers | 626 | 32.0 | 1328 | 68.0 | ||
| Ex-smokers | 986 | 35.0 | 1835 | 65.0 | Ex-smokers to smokers | 0.88 (0.78, 0.99); p<0.001 |
| Non-smokers | 404 | 52.3 | 369 | 47.7 | Non-smokers to smokers | 0.43 (0.36, 0.51); p<0.001 |
| FEV1c, mean (±SD) | 1.85 (±0.75) | 1.46 (±0.64) | Per litre | 0.45 (0.41, 0.49); p<0.0001 | ||
| FEV1/FVCd, mean (±SD) | 72.5 (±14.7) | 61.8 (±14.4) | Per 10% | 0.58 (0.54, 0.61); p<0.001 | ||
Missing for 7 patients.
Missing for 173 patients.
Missing for 402 patients.
Missing for 2783 patients.
Note: Odds ratios apply to the risk of that variable contributing to a change of diagnosis.
Missing for 2 patients.
Missing for 732 patients.
Missing for 2827 patients.
Missing for 9703 patients.
Note: Odds ratios apply to the risk of that variable contributing to a change of diagnosis.
Missing for 3 patients.
Not significant.
Missing for 212 patients.
Missing for 879 patients.
Note: Odds ratios apply to the risk of that variable contributing to a change of diagnosis.
Missing for 7 patients.
Missing for 173 patients.
Missing for 402 patients.
Missing for 2783 patients.
Note: Odds ratios apply to the risk of that variable contributing to a change of diagnosis.