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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Blood Cells Mol Dis. 2009 Apr 5;43(1):58–62. doi: 10.1016/j.bcmd.2009.02.006

Figure 4. Comparison of the effects of butyrate and hemin on the expression of the γ-, β- and α-globin genes in the progenitor cells of the same patients with β-thal.

Figure 4

Mononuclear cells from patients with β-Thal (#2, 3, 5, 6, 8&9) were cultured into BFU-E derived colonies in absence (control) or presence (drug) of 150 μM butyrate or 100μM hemin. mRNA levels were measured by quantitative real-time RT-PCR and expressed as % γ/(β+ γ), fold change relative to the control and ratio α/(β+γ). In each experiment, each sample had triplicates