Table 3.
Probes whose expressions are altered by at least a log2 ratio of ±0.5 in nine-month-old transgenic α-syn mice. P value for each probe is ≤0.05 and q-value is ≤20%.
| Probe Set ID | Genbank ID | Gene Name | log2 (TG/WT) | q-value |
|---|---|---|---|---|
| 1436964_at | BB314814 | DNA SEGMENT, CHR 7, ERATO DOI 715, EXPRESSED | -2.78 | 18.07 |
| 1442568_at | BM213120 | RIKEN CDNA 3110039L19 GENE | -1.98 | 18.07 |
| 1443281_at | BB297094 | RIKEN CDNA C030017F07 GENE | -1.61 | 8.66 |
| 1442742_at | BE994454 | RIKEN CDNA 1700121J11 GENE | -1.55 | 17.17 |
| 1440773_at | BB209878 | F-BOX ONLY PROTEIN 8 | -1.37 | 8.51 |
| 1440163_at | BB392503 | RIKEN CDNA 6030490B17 GENE | -1.33 | 8.51 |
| 1430660_at | AV291471 | RIKEN CDNA 2610100B20 GENE | -1.31 | 11.70 |
| 1431248_at | BB637274 | RIKEN CDNA 5031426D15 GENE | -1.26 | 8.66 |
| 1426413_at | BM116592 | NEUROGENIC DIFFERENTIATION 1 | -1.22 | 17.17 |
| 1455512_at | AI852151 | GENE MODEL 879, (NCBI) | -1.20 | 8.66 |
| 1455956_x_at | AV310588 | CYCLIN D2 | -1.17 | 10.02 |
| 1429769_at | BI107300 | PROTEIN GERANYLGERANYLTRANSFERASE TYPE I, BETA SUBUNIT | -1.12 | 8.66 |
| 1451301_at | BB633110 | TROPOMODULIN 2 | -1.06 | 8.51 |
| 1426721_s_at | BB707122 | TCDD-INDUCIBLE POLY(ADP-RIBOSE) POLYMERASE | -1.02 | 0.00 |
| 1440304_at | BB085100 | EXPRESSED SEQUENCE BB214985 | -0.99 | 8.51 |
| 1455393_at | BB009037 | CERULOPLASMIN | -0.95 | 17.17 |
| 1422795_at | AV273804 | CULLIN 3 | -0.95 | 12.54 |
| 1434216_a_at | BG070689 | NUDIX (NUCLEOSIDE DIPHOSPHATE LINKED MOIETY X)-TYPE MOTIF 19 | -0.95 | 18.07 |
| 1432944_at | AK013658 | RIKEN CDNA 2900046L07 GENE | -0.94 | 0.00 |
| 1450061_at | BM120053 | ECTODERMAL-NEURAL CORTEX 1 | -0.93 | 8.66 |
| 1440534_at | BB177862 | RIKEN CDNA 6330403A02 GENE | -0.93 | 15.94 |
| 1457198_at | AV291009 | NEUROPILIN 1 | -0.92 | 17.17 |
| 1447314_at | AI480643 | TRANSFORMING GROWTH FACTOR, BETA RECEPTOR III | -0.91 | 10.02 |
| 1429703_at | AV154947 | RIKEN CDNA 2900072G11 GENE | -0.90 | 0.00 |
| 1442214_at | BG173293 | NUCLEAR FACTOR I/B | -0.90 | 8.51 |
| 1433184_at | AK020162 | RIKEN CDNA 6720477C19 GENE | -0.89 | 15.02 |
| 1424525_at | BC024515 | GASTRIN RELEASING PEPTIDE | -0.89 | 13.49 |
| 1454286_at | AV007471 | RIKEN CDNA 1110004M10 GENE | -0.88 | 12.54 |
| 1458263_at | BE979587 | CUG TRIPLET REPEAT, RNA BINDING PROTEIN 2 | -0.87 | 0.00 |
| 1453402_at | AV338754 | RIKEN CDNA 6430500C12 GENE | -0.86 | 10.02 |
| 1459144_at | BB518323 | HYPOTHETICAL PROTEIN LOC213817 | -0.85 | 13.49 |
| 1430808_at | AK005461 | TBC1 DOMAIN FAMILY, MEMBER 5 | -0.85 | 10.02 |
| 1420965_a_at | BM120053 | ECTODERMAL-NEURAL CORTEX 1 | -0.84 | 10.66 |
| 1445391_at | AW554652 | DIAPHANOUS HOMOLOG 1 (DROSOPHILA) | -0.83 | 19.25 |
| 1455914_at | AW554430 | EXPRESSED SEQUENCE AI987944 | -0.82 | 19.25 |
| 1435129_at | AW495875 | PROTEIN TYROSINE PHOSPHATASE 4A2 | -0.81 | 10.02 |
| 1444557_at | BG060557 | SMT3 SUPPRESSOR OF MIF TWO 3 HOMOLOG 1 (YEAST) | -0.81 | 8.66 |
| 1439940_at | AV328280 | RIKEN CDNA 2900019G14 GENE | -0.80 | 19.25 |
| 1443526_at | BM204661 | PHD FINGER PROTEIN 21A | -0.80 | 0.00 |
| 1439123_at | BB367687 | PHD FINGER PROTEIN 21A | -0.79 | 15.02 |
| 1445708_x_at | AV158652 | RIKEN CDNA 3110021A11 GENE | -0.79 | 19.25 |
| 1453068_at | BM226301 | PR DOMAIN CONTAINING 2, WITH ZNF DOMAIN | -0.78 | 19.25 |
| 1446953_at | BG073799 | TRANSCRIPTION FACTOR 4 | -0.77 | 8.66 |
| 1445037_at | AV339661 | RIKEN CDNA 6430510B20 GENE | -0.77 | 10.02 |
| 1437793_at | BB711615 | TANKYRASE, TRF1-INTERACTING ANKYRIN-RELATED ADP-RIBOSE POLYMERASE 2 | -0.76 | 8.51 |
| 1446374_at | BB460605 | RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10 | -0.76 | 12.54 |
| 1442500_at | C77406 | EXPRESSED SEQUENCE C77406 | -0.76 | 10.02 |
| 1460186_at | AV061337 | RIKEN CDNA 1810073M23 GENE | -0.76 | 19.25 |
| 1441538_at | BB267954 | RIKEN CDNA B930011P16 GENE | -0.75 | 17.17 |
| 1442409_at | BB166984 | DNA SEGMENT, CHR 9, WAYNE STATE UNIVERSITY 90, EXPRESSED | -0.74 | 19.25 |
| 1429051_s_at | BE825056 | SRY-BOX CONTAINING GENE 11 | -0.74 | 13.49 |
| 1444472_at | BB154631 | SNF1-LIKE KINASE 2 | -0.74 | 13.49 |
| 1440728_at | BB283560 | POTASSIUM LARGE CONDUCTANCE CALCIUM-ACTIVATED CHANNEL, SUBFAMILY M, ALPHA MEMBER 1 | -0.74 | 18.07 |
| 1437180_at | BE824567 | RIKEN CDNA 6530403A03 GENE | -0.73 | 0.00 |
| 1439169_at | BB471557 | EUKARYOTIC TRANSLATION INITIATION FACTOR 4E NUCLEAR IMPORT FACTOR 1 | -0.73 | 13.49 |
| 1449068_at | X98096 | ZINC FINGER PROTEIN 148 | -0.72 | 8.66 |
| 1434835_at | BM230523 | CDNA SEQUENCE BC037674 | -0.72 | 17.17 |
| 1432352_at | AK014201 | RIKEN CDNA 5730405I09 GENE | -0.71 | 17.17 |
| 1446159_at | BB044011 | P21 (CDKN1A)-ACTIVATED KINASE 7 | -0.71 | 8.51 |
| 1454510_at | AK013612 | RIKEN CDNA 2900034C19 GENE | -0.71 | 8.51 |
| 1444785_at | AI503808 | SLOAN-KETTERING VIRAL ONCOGENE HOMOLOG | -0.71 | 12.54 |
| 1442659_at | BB244656 | PROTOCADHERIN 9 | -0.70 | 13.49 |
| 1423433_at | BG069917 | TROVE DOMAIN FAMILY, MEMBER 2 | -0.69 | 8.51 |
| 1448282_at | BC006750 | PLEIOTROPIC REGULATOR 1, PRL1 HOMOLOG (ARABIDOPSIS) | -0.69 | 11.70 |
| 1460123_at | AW541072 | G PROTEIN-COUPLED RECEPTOR 1 | -0.69 | 17.17 |
| 1453864_at | AK014097 | RIKEN CDNA 3110030G19 GENE | -0.69 | 19.25 |
| 1445847_at | BE948333 | NEUROTROPHIC TYROSINE KINASE, RECEPTOR, TYPE 2 | -0.69 | 18.07 |
| 1459219_at | BM120546 | RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2 | -0.68 | 10.02 |
| 1458469_at | BB205662 | CASITAS B-LINEAGE LYMPHOMA B | -0.68 | 12.54 |
| 1459238_at | AV319481 | PHOSPHOLAMBAN | -0.68 | 8.51 |
| 1441072_at | BB353142 | CUG TRIPLET REPEAT, RNA BINDING PROTEIN 2 | -0.67 | 10.02 |
| 1416892_s_at | BC021353 | RIKEN CDNA 3110001A13 GENE | -0.67 | 8.51 |
| 1459734_at | BB737833 | PROTEASOME (PROSOME, MACROPAIN) 26S SUBUNIT, NON-ATPASE, 14 | -0.67 | 17.17 |
| 1430675_at | BM932606 | RIKEN CDNA 2900055J20 GENE | -0.67 | 18.07 |
| 1434378_a_at | BG868949 | MAX DIMERIZATION PROTEIN 4 | -0.67 | 8.51 |
| 1436248_at | AW120749 | RAS PROTEIN ACTIVATOR LIKE 2 | -0.67 | 8.51 |
| 1441487_at | BB197646 | TRIPARTITE MOTIF PROTEIN 2 | -0.66 | 18.07 |
| 1442679_at | BM241898 | MITOGEN ACTIVATED PROTEIN KINASE KINASE 4 | -0.66 | 17.17 |
| 1451506_at | BB280300 | MYOCYTE ENHANCER FACTOR 2C | -0.66 | 15.02 |
| 1428936_at | BI080417 | ATPASE, CA++ TRANSPORTING, PLASMA MEMBRANE 1 | -0.66 | 10.02 |
| 1438282_at | AV344830 | SYNAPTOTAGMIN I | -0.66 | 10.66 |
| 1434178_at | AV297525 | MYELOID/LYMPHOID OR MIXED-LINEAGE LEUKEMIA 3 | -0.66 | 13.58 |
| 1454424_at | AK011729 | RIKEN CDNA 2610040L17 GENE | -0.66 | 8.66 |
| 1455799_at | BB751387 | RAR-RELATED ORPHAN RECEPTOR BETA | -0.66 | 8.51 |
| 1443508_at | BB131767 | EXPRESSED SEQUENCE BB075781 | -0.65 | 17.17 |
| 1420579_s_at | NM_021050 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR HOMOLOG | -0.65 | 12.54 |
| 1458376_at | BE648536 | RIKEN CDNA B930025B16 GENE | -0.65 | 18.07 |
| 1458690_at | BB079254 | MEMBRANE-ASSOCIATED RING FINGER (C3HC4) 7 | -0.65 | 15.02 |
| 1439209_at | BB540782 | TRANSCRIPTION FACTOR 12 | -0.65 | 12.54 |
| 1416129_at | NM_133753 | ERBB RECEPTOR FEEDBACK INHIBITOR 1 | -0.65 | 8.66 |
| 1443260_at | BB055155 | MYELOID ECOTROPIC VIRAL INTEGRATION SITE 1 | -0.64 | 11.70 |
| 1437064_at | AV232123 | ANDROGEN RECEPTOR | -0.64 | 17.17 |
| 1418955_at | NM_009567 | ZINC FINGER PROTEIN 93 | -0.64 | 8.51 |
| 1454743_at | BQ177153 | NUCLEOPORIN 205 | -0.64 | 10.66 |
| 1435505_at | BB698273 | DYSTROPHIA MYOTONICA-CONTAINING WD REPEAT MOTIF | -0.64 | 15.02 |
| 1445340_at | BB156822 | PAM, HIGHWIRE, RPM 1 | -0.64 | 0.00 |
| 1431482_at | AV153257 | RIKEN CDNA 2900012M01 GENE | -0.63 | 18.07 |
| 1426546_at | BQ179435 | TESTIS-SPECIFIC KINASE 2 | -0.62 | 15.94 |
| 1444409_at | BQ176035 | RABPHILIN 3A-LIKE (WITHOUT C2 DOMAINS) | -0.62 | 10.66 |
| 1420136_a_at | AI427540 | OPIOID GROWTH FACTOR RECEPTOR-LIKE 1 | -0.62 | 19.25 |
| 1441231_at | BB233964 | GENE MODEL 1167, (NCBI) | -0.62 | 15.94 |
| 1456896_at | BB053380 | RIKEN CDNA 6720462K09 GENE | -0.62 | 18.07 |
| 1454922_at | BM246326 | EXPRESSED SEQUENCE AI553587 | -0.62 | 13.49 |
| 1456413_at | BB235927 | PHOSPHODIESTERASE 4D INTERACTING PROTEIN | -0.61 | 8.66 |
| 1441654_at | BB345762 | GUANINE NUCLEOTIDE BINDING PROTEIN, ALPHA 10 | -0.61 | 19.25 |
| 1428616_at | BG075140 | ZINC FINGER PROTEIN 131 | -0.61 | 17.17 |
| 1459947_at | BB007036 | THIOREDOXIN DOMAIN CONTAINING 5 | -0.61 | 15.02 |
| 1444516_at | AI503166 | PROTEIN TYROSINE PHOSPHATASE, RECEPTOR-TYPE, F INTERACTING PROTEIN, BINDING PROTEIN 2 | -0.61 | 13.58 |
| 1438245_at | BI664122 | NUCLEAR FACTOR I/B | -0.61 | 8.66 |
| 1435663_at | AI646838 | ESTROGEN RECEPTOR 1 (ALPHA) | -0.60 | 18.07 |
| 1430195_at | BF662697 | RIKEN CDNA 2810043O03 GENE | -0.60 | 15.94 |
| 1437426_at | BM240080 | RIKEN CDNA 1110067P07 GENE | -0.60 | 8.66 |
| 1437984_x_at | BB461609 | HLA-B-ASSOCIATED TRANSCRIPT 1A | -0.59 | 17.17 |
| 1437339_s_at | BB241731 | PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 5 | -0.59 | 18.07 |
| 1439106_at | AV320128 | ZINC FINGER PROTEIN 462 | -0.59 | 10.66 |
| 1457019_s_at | BB241474 | RIKEN CDNA 3110030G19 GENE | -0.59 | 13.49 |
| 1417644_at | BC021484 | SARCOSPAN | -0.59 | 18.07 |
| 1437784_at | AW550878 | CBFA2T1 IDENTIFIED GENE HOMOLOG (HUMAN) | -0.59 | 17.17 |
| 1435474_at | AV117817 | TAF5 RNA POLYMERASE II, TATA BOX BINDING PROTEIN (TBP)-ASSOCIATED FACTOR | -0.59 | 18.07 |
| 1445774_at | BB479183 | POTASSIUM LARGE CONDUCTANCE CALCIUM-ACTIVATED CHANNEL, SUBFAMILY M, ALPHA MEMBER 1 | -0.59 | 8.51 |
| 1440020_at | BB212045 | EXPRESSED SEQUENCE AI195322 | -0.59 | 10.66 |
| 1438352_at | BM217851 | MICROTUBULE-ASSOCIATED PROTEIN, RP/EB FAMILY, MEMBER 2 | -0.58 | 18.07 |
| 1430058_at | AK016826 | STEM-LOOP BINDING PROTEIN | -0.58 | 15.94 |
| 1430291_at | AK004325 | RIKEN CDNA 1110060D06 GENE | -0.58 | 19.25 |
| 1452092_at | AK019474 | RIKEN CDNA 4631426J05 GENE | -0.58 | 12.54 |
| 1446670_at | BM241206 | CUG TRIPLET REPEAT, RNA BINDING PROTEIN 2 | -0.57 | 13.58 |
| 1444186_at | BB519728 | RIKEN CDNA 2900006B13 GENE | -0.57 | 15.02 |
| 1421948_a_at | BB042564 | RIKEN CDNA 2610507L03 GENE | -0.57 | 18.07 |
| 1441100_at | BB496952 | MBT DOMAIN CONTAINING 1 | -0.57 | 15.94 |
| 1446272_at | BB200545 | RIKEN CDNA 6430598J10 GENE | -0.57 | 11.70 |
| 1443161_at | BM240648 | TRICHORHINOPHALANGEAL SYNDROME I (HUMAN) | -0.57 | 8.66 |
| 1446750_at | BB524087 | IMPRINTED AND ANCIENT | -0.57 | 11.70 |
| 1439174_at | AI644595 | UNC-5 HOMOLOG C (C. ELEGANS) | -0.57 | 10.02 |
| 1431228_s_at | AA120741 | RIKEN CDNA 4930526I15 GENE | -0.56 | 15.02 |
| 1417818_at | BC014727 | WW DOMAIN CONTAINING TRANSCRIPTION REGULATOR 1 | -0.56 | 18.07 |
| 1444456_at | BB460570 | RIKEN CDNA 9030425P06 GENE | -0.56 | 13.49 |
| 1435433_at | BE688580 | EXPRESSED SEQUENCE R75364 | -0.56 | 18.07 |
| 1457716_at | BM235074 | ZINC FINGER, A20 DOMAIN CONTAINING 1 | -0.55 | 18.07 |
| 1453416_at | BE199211 | GROWTH ARREST-SPECIFIC 2 LIKE 3 | -0.55 | 15.02 |
| 1443337_at | BB531021 | RIKEN CDNA B130020M22 GENE | -0.55 | 19.25 |
| 1442587_at | BB451946 | RIKEN CDNA C030017F07 GENE | -0.55 | 19.25 |
| 1441545_at | BM243297 | RIKEN CDNA 9230115F04 GENE | -0.55 | 12.54 |
| 1437676_at | AV279478 | SPERM ASSOCIATED ANTIGEN 9 | -0.54 | 8.51 |
| 1431402_at | BB626088 | KIN OF IRRE LIKE 3 (DROSOPHILA) | -0.54 | 19.25 |
| 1447204_at | BB337014 | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5 | -0.54 | 10.02 |
| 1418168_at | BB223737 | ZINC FINGER, CCHC DOMAIN CONTAINING 14 | -0.53 | 8.51 |
| 1440770_at | AI505544 | B-CELL LEUKEMIA/LYMPHOMA 2 | -0.53 | 19.25 |
| 1457781_at | BG063584 | KCNQ1 OVERLAPPING TRANSCRIPT 1 | -0.53 | 10.02 |
| 1434829_at | BB487560 | CASITAS B-LINEAGE LYMPHOMA | -0.53 | 8.51 |
| 1442924_at | BB430910 | CALSYNTENIN 2 | -0.53 | 15.02 |
| 1422486_a_at | AK004804 | MAD HOMOLOG 4 (DROSOPHILA) | -0.53 | 17.17 |
| 1454182_at | AK019946 | RIKEN CDNA 5430417C01 GENE | -0.53 | 11.70 |
| 1438535_at | BB523030 | NEURONAL DIFFERENTIATION RELATED PROTEIN | -0.52 | 19.25 |
| 1429652_at | AK009976 | RIKEN CDNA 1190002C06 GENE | -0.52 | 8.51 |
| 1439626_at | BB209799 | TROPOMODULIN 3 | -0.52 | 15.02 |
| 1439192_at | BB524078 | NEURO-ONCOLOGICAL VENTRAL ANTIGEN 2 | -0.52 | 19.25 |
| 1415925_a_at | NM_053074 | NUCLEOPORIN 62 | -0.52 | 13.58 |
| 1454852_at | BB795189 | TRANS-ACTING TRANSCRIPTION FACTOR 1 | -0.52 | 15.94 |
| 1433543_at | BI690018 | ANILLIN, ACTIN BINDING PROTEIN (SCRAPS HOMOLOG, DROSOPHILA) | -0.52 | 13.49 |
| 1442320_at | BB364132 | HYPOTHETICAL LOC553096 | -0.52 | 19.25 |
| 1453371_at | AK012860 | RIKEN CDNA 4930535B03 GENE | -0.51 | 18.07 |
| 1455225_at | AV237615 | SYNAPTIC NUCLEAR ENVELOPE 1 | -0.51 | 18.07 |
| 1433641_at | AV014063 | MAD HOMOLOG 5 (DROSOPHILA) | -0.51 | 17.17 |
| 1440311_at | BB259710 | SORBIN AND SH3 DOMAIN CONTAINING 1 | -0.51 | 19.25 |
| 1436795_at | BM247060 | RIKEN CDNA 9630058J23 GENE | -0.51 | 10.66 |
| 1433803_at | BQ032637 | JANUS KINASE 1 | -0.51 | 18.07 |
| 1458053_at | BB051811 | ABL-INTERACTOR 2 | -0.51 | 18.07 |
| 1429918_at | AK018317 | RIKEN CDNA 6530403F17 GENE | -0.51 | 11.70 |
| 1443020_at | BB027719 | RIKEN CDNA F830020C16 GENE | -0.51 | 8.66 |
| 1455854_a_at | BB053082 | SLINGSHOT HOMOLOG 1 (DROSOPHILA) | -0.50 | 19.25 |
| 1446965_at | BG067578 | RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 | -0.50 | 18.07 |
| 1441635_at | BM202709 | NUCLEAR RECEPTOR SUBFAMILY 6, GROUP A, MEMBER 1 | -0.50 | 18.07 |
| 1418000_a_at | NM_008410 | INTEGRAL MEMBRANE PROTEIN 2B | -0.50 | 8.51 |
| 1428368_at | BM213829 | RHO GTPASE ACTIVATING PROTEIN 21 | 0.51 | 15.94 |
| 1418506_a_at | NM_011563 | PEROXIREDOXIN 2 | 0.55 | 17.17 |
| 1416028_a_at | NM_008258 | HEMATOLOGICAL AND NEUROLOGICAL EXPRESSED SEQUENCE 1 | 0.58 | 15.02 |
| 1426448_at | BM199789 | PRAJA1, RING-H2 MOTIF CONTAINING | 0.58 | 15.02 |
| 1420828_s_at | NM_011739 | TYROSINE 3-MONOOXYGENASE/TRYPTOPHAN 5-MONOOXYGENASE ACTIVATION PROTEIN, THETA POLYPEPTIDE | 0.65 | 15.94 |
| 1435258_at | AW551717 | DNA SEGMENT, CHR 2, ERATO DOI 217, EXPRESSED | 0.66 | 15.02 |
| 1421873_s_at | NM_009000 | RAB24, MEMBER RAS ONCOGENE FAMILY | 0.67 | 15.02 |
| 1450243_a_at | NM_030598 | DOWN SYNDROME CRITICAL REGION GENE 1-LIKE 1 | 0.72 | 15.02 |
| 1433799_at | AV366849 | RETINOL DEHYDROGENASE 13 (ALL-TRANS AND 9-CIS) | 0.79 | 10.66 |
| 1415773_at | BF118393 | NUCLEOLIN | 0.85 | 10.66 |
| 1455868_a_at | BB387906 | TUBULIN, GAMMA COMPLEX ASSOCIATED PROTEIN 2 | 0.86 | 15.02 |
| 1428370_at | AK018264 | RIKEN CDNA 1500011B03 GENE | 1.02 | 7.49 |
| 1448732_at | M14222 | CATHEPSIN B | 1.25 | 15.02 |
| AFFX-GapdhMur/M32599_5_at | AFFX-GapdhMur/M3259 9_5 | SIMILAR TO GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH) | 1.57 | 15.02 |