Table 1.
Antiviral Agent |
Primary antiviral resistant mutation |
Frequency of resistance at 1 year |
Preferred Management |
|
---|---|---|---|---|
HBeAg (+) | HBeAg(−) | |||
Lamivudine | rtM204V/I rtA181V/T |
15–30%31, 32 | 11–27%81, 82 | Add adefovir Add or switch to tenefovir |
Telbivudine | rtM204I | 5%12 | 2%12 | Add adefovir Add or switch to tenefovir |
Adefovir | rtA181V/T rtN236T |
0%83 | 0%84 | Add lamivudine or telbivudine Switch to tenofovir Switch to entecavir |
Tenofovir | None | 0%45 | 0%45 | |
Entecavir | rtL180M & rtM204V plus rtI169T & rtM250V or rtT184G & rtS202I |
0%52 | 0%34 | ? Add adefovir Add or switch to tenofovir |