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. Author manuscript; available in PMC: 2009 Jul 9.
Published in final edited form as: Immunity. 2009 Feb 5;30(2):242–253. doi: 10.1016/j.immuni.2008.11.012

Figure 1. Increased Susceptibility of Tlr7−/− and Myd88−/− Mice, but Not Tlr9−/− Mice, after West Nile Virus Challenge.

Figure 1

Wild-type mice (n = 24), Tlr7−/− mice (n = 22), Myd88−/− mice (n = 13), and Tlr9−/− mice (n = 14) were i.p. infected with WNV (LD50) and monitored twice daily for 21 days for mortality. Data shown are represented as time after infection (days) on the x axis and percent survival (%) on the y axis. Kaplan-Meier survival analysis revealed significant differences between wild-type and Tlr7−/− or Myd88−/− mice, but not between wild-type and Tlr9−/− mice. Data shown are pooled from 2–4 independent experiments.