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. Author manuscript; available in PMC: 2009 Jul 9.
Published in final edited form as: Chem Biol. 2007 Aug;14(8):944–954. doi: 10.1016/j.chembiol.2007.07.013

Figure 7. Proposed Model of 10-Deoxymethynolide Formation by the Pikromyin Polyketide Synthase.

Figure 7

Based on the current in vitro data, the efficient production of 10-deoxymethynolide by the pikromycin PKS system requires that PikAIII and PikAIV be engaged in their docking domain mediated protein-protein interaction. A presumed conformational flexibility of PikAIV enables the thioesterase domain to directly off-load the hexaketide intermediate from PikAIII to generate the 12-membered macrolactone product.