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. Author manuscript; available in PMC: 2009 Jul 9.
Published in final edited form as: Immunity. 2007 Jul 12;27(1):111–122. doi: 10.1016/j.immuni.2007.05.016

Figure 1. Equilibrium binding constants of B7-1 and PD-L1 interactions.

Figure 1

A) Equilibrium binding responses were measured using surface plasmon resonance of fusion proteins of B7-1, B7-2, and PD-1 to immobilized PD-L1 and PD-L2 fusion proteins. No binding response was seen for B7-2 to PD-L1 or PD-L2 (not shown). The Kds for the three significant interactions are shown (arrows).

B) Scatchard plot shows the dissociation constant for B7-1 to immobilized PD-L1 is 1.6 μM. The linear fit and its 90% confidence interval are shown.

C) Summary of dissociation constants obtained from Biacore equilibrium binding experiments.

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