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. Author manuscript; available in PMC: 2009 Jul 9.
Published in final edited form as: Immunity. 2007 Jul 12;27(1):111–122. doi: 10.1016/j.immuni.2007.05.016

Figure 5. Markers of activation are diminished in CD28/CTLA-4-/- T cells stimulated with anti-CD3 plus B7-1.

Figure 5

CD28/CTLA4-/- CD4 T cells were cultured with beads coated with anti-CD3 plus either B7-1-Ig (“B7-1”) or hIgG1Fc (“Ig”). T cells were then stained and analyzed by FACS after 24 or 48 hours for A. activation markers and B. costimulatory receptors and ligands. Shaded histogram indicates control cells.