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. Author manuscript; available in PMC: 2009 Jul 9.
Published in final edited form as: Immunity. 2007 Jul 12;27(1):111–122. doi: 10.1016/j.immuni.2007.05.016

Figure 7. Specificity of B7-1:PD-L1 interactions.

Figure 7

A. WT, CD28/CTLA-4-/-, or CD28/CTLA-4/PD-L1-/- CD4 T cells were cultured in wells coated with anti-CD3 antibody (10 μg/mL) plus either PD-L1-Ig (10 μg/mL) or control Ig (10 μg/mL). CFSE dilution was examined by flow cytometry at 48 hours.

B. WT, PD-1-/-, or PD-1/B7-1-/- CD4 T cells were cultured in wells coated with anti-CD3 antibody (5 μg/mL) plus either PD-L1-Ig (10 μg/mL) or control Ig (10 μg/mL). CFSE dilution was examined by flow cytometry at 48 hours.

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