Table 1.
Effect of HHcy on the Emax (mN·mg−1) and pD2 values for endothelin-1 in rat carotid arteries in the absence or presence of BQ123 (1 µmol·L−1) or BQ788 (0.1 µmol·L−1)
|
Control |
HHcy |
|||
|---|---|---|---|---|
| Emax | pD2 | Emax | pD2 | |
| 7.29 ± 0.65 | 8.92 ± 0.09 | 13.82 ± 0.07 | 8.99 ± 0.06 | |
| BQ123 (1 µmol·L−1) | 5.15 ± 0.99* | 7.94 ± 0.10* | 6.35 ± 0.09* | 8.00 ± 0.09* |
| BQ788 (0.1 µmol·L−1) | 5.28 ± 0.33* | 8.48 ± 0.09* | 9.25 ± 0.05* | 8.46 ± 0.08* |
Values are means ± SEM of n= 7 preparations.
*
Compared with respective control in the absence of antagonists (P < 0.05; one-way anova).