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The effect of intrathecal dehydroepiandrosterone sulphate (DHEAS) (300 pmol per mouse) administered 5 min after i.t. pretreatment with BD-1047 (A) or muscimol (B) on the nociceptive threshold to mechanical stimulation. Data are presented as a percentage of the pre-baseline values. **P < 0.01, *P < 0.05: different from the vehicle control group [saline + 1% dimethyl sulphoxide (DMSO) in saline] value; n= 7 mice per group.
