Figure 1.

Comparison of (A) the structures between piceatannol and resveratrol and the different response to both polyphenols in (B) the APs and (C) the action-potential-clamp-elicited inward currents in rat ventricular cells. (B) The superimposed APs were elicited at 1 Hz in current clamp mode, and the steady-state recordings in the absence or presence of the cumulatively increasing doses of either piceatannol or resveratrol were shown. The dash lines indicate the membrane potential at zero. (C) The AP contour of rat papillary muscle stimulated at 1 Hz was employed as the voltage protocol to record the inward currents affected by either piceatannol or resveratrol. Cs⁺ plus TEA-containing pipette internal solution was used to block potassium currents in addition to the presence of 10 mmol·L⁻¹ Cs⁺ in the bath solution.