Table 1.
Summary of the experimental conditions
| Group 1 | Group 2 | Group 3 | Group 4 | |
|---|---|---|---|---|
| Experiment 1 (mg·kg−1) | Control saline | Danshensu (20) | Danshensu (20) | |
| Tolcapone (10) | ||||
| Experiment 2 (mg·kg−1) | Control saline | Methionine (0.8) | Methionine (0.8) | Methionine (0.8) |
| Danshensu (10) | Danshensu (20) | |||
| Experiment 3 (mg·kg−1·day−1) | Control saline | Danshensu (5) | Methionine (0.8) | Methionine (0.8) |
| n= 10 | n= 10 | Danshensu (5) | ||
| Experiment 4 (mg·kg−1) | Control saline | Danshensu (20) | ||
| Experiment 5 | Control saline | Methionine (0.8) | ||
| Experiment 6 (mg·kg−1·day−1) | Control saline | Danshensu (5) | Methionine (0.8) | Methionine (0.8) |
| Danshensu (5) |
Numbers in parentheses denote doses; for danshensu and tolcapone these are as mg·kg−1; for methionine, as mmol·kg−1. Experiments 1, 2, 4 and 5 involved a single i.v. dose of danshensu or methionine; experiments 3 and 6 involved chronic treatment with danshensu methionine or both given i.p., once daily for 3 weeks; n= 5 for all the groups except when otherwise indicated.