. 2009 Apr 30;157(3):482–490. doi: 10.1111/j.1476-5381.2009.00179.x

Table 2.

Some pharmacokinetic parameters of plasma total homocysteine (tHcy) in rats treated with danshensu (DSS) and methionine (Met)

Parameters	DSS	Met	DSS(L)+Met	DSS(H)+Met	pre-DSS+Met
C_max (µmol·L⁻¹)	27 ± 16	45 ± 12	37 ± 4^* (18%)^a	34 ± 3^* (24%)^a	25 ± 10^** (44%)^a
T_max (min)	28 ± 19	96 ± 33	96 ± 33	78 ± 40	87 ± 48
ΔAUC_{0–4 h} (µmol·L⁻¹·min)	1744 ± 1791	5449 ± 1156	4277 ± 874^* (22%)^a	3352 ± 893^*^▾(35%)^a	1129 ± 1142^** (79%)^a

P < 0.05

^**

P < 0.01 compared with group Met.

^▾

P < 0.05 compared with group DSS(L) + Met (Student's t-test). Values in parentheses for the AUV represent the % reduction, relative to the value with Met alone = 100%.

DSS, rats were given i.v. danshensu alone (20 mg·kg⁻¹). Met, rats were given i.v. methionine alone (0.8 mmol·kg⁻¹). DSS(H) + Met, rats were given i.v. methionine (0.8 mmol·kg⁻¹) with high dose DSS (20 mg·kg⁻¹). DSS(L) + Met, rats were given i.v. methionine (0.8 mmol·kg⁻¹) with low dose DSS (10 mg·kg⁻¹). pre-DSS + Met, rats were given i.p. danshensu 5 mg·kg⁻¹·day⁻¹ for 3 weeks and washed out (no treatment) for 3 days, then i.v. methionine (0.8 mmol·kg⁻¹).

Each value is the mean ± SD for five rats except for pre-DSS + Met (n= 4 rats).