Effects of nicotine on neurotensin-like immunoreactivity (NTLI) content in other dopamine-related systems such as the substantia nigra (Fig. 5A), very anterior striatum (Fig. 5B), medial anterior striatum (Fig. 5C), and lateral anterior striatum (Fig. 5D). Animals were given injections of nicotine (as described for Fig. 1) or saline and killed 12 and 24 h following the treatment. Results are expressed as percentages of control and represent mean values ± S.E.M. (n= 8 control and 9 drug-treated animals per group). The average control values of NTLI concentrations for substantia nigra, very anterior striatum, medial anterior striatum, and lateral anterior striatum were 545 ± 60 pg/mg protein, 114 ± 12 pg/mg protein, 158 ± 17 pg/mg protein, and 80 ± 4 pg/mg protein, respectively. *P < 0.05 vs. control.