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. 2009 Feb;18(2):410–423. doi: 10.1002/pro.44

Figure 5.

Figure 5

(a) Order parameters (S2) for mPrP(113–231). Order parameters describe the amplitude range of the nanosecond time-scale motions between 0 (flexible) and 1.0 (rigid). Residues that exhibit additional Rex exchange motions are highlighted in red. (b) Order parameter mapped onto the structure (1 xyx) of mPrPC: red S2 > 1.0 (Rex motions); blue 0.85 < S2 < 1.0; cyan 0.75 < S2 < 0.85; green 0.65 < S2 < 0.75; and yellow S2 < 0.65, residues in gray have no value calculated. (c) Slow conformational fluctuations are localized to a distinct region within PrPC, the position of side-chains that exhibit Rex motions are highlighted, dots are proton positions. (d) The molecular surface, in red, generated by the residues that exhibit Rex motions, within the context of the whole structured domain. This figure was generated using GRASP2.