Figure 3.

Use of evolutionary conservation data to obtain candidates to FGFR-TM homodimerization. (a) Alignment of FGFR-TM sequences. A systematic search was performed with sequence 369–395 (numbering corresponding to human FGFR3-TM). (b) Evolutionary conserved homodimeric structures obtained after exploring all possible conformational space of FGFR-TM homodimers. Low energy structures are indicated and plotted on a plane (x axis, helix tilt; y axis, rotational orientation for residue V381, ω₃₈₁). Three “complete sets,” are indicated by circles.