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. Author manuscript; available in PMC: 2010 Mar 26.
Published in final edited form as: J Med Chem. 2009 Mar 26;52(6):1602–1611. doi: 10.1021/jm8005806

Figure 1.

Figure 1

A) Screening of an 58-member organometallic pyridocarbazole library against MST1. Histogram with % activity represented on the y-axis plotted against the compound identifier on the x-axis. See supporting information for the identity of the compounds other than 1-3. The screen was carried out at a compound concentration of 5 μM, an MST1 concentration of 50 nM and an ATP concentration of 100 μM. B) Chemical structures of the three identified hits. C) The IC50 curve for compound 2. Final MST1 concentration used was 1 nM in the presence of 100 μM ATP. The GraphPad Prism software was used to make the graphs.