Table 2.
Chronic kidney disease (CKD), ejection fraction (EF) and all-cause mortality in heart failure (HF)
| Death/total follow up in year (Death rate Per 10,000 person-years of follow-up) |
Rate difference (Per 10,000 Person- Years) | Hazard ratio (95% CI) | Adjusted* hazard ratio (95% CI) | |||
|---|---|---|---|---|---|---|
| All patients | No CKD | CKD | ||||
| All (N=4798) | 1639 / 14093 (1163) | 757 / 7216 (1049) | 882 / 6877 (1282) | 233 | 1.22 (1.09 – 1.36); p<0.0001 | 1.26 (1.12 – 1.42); p<0.0001 |
| EF <=45% (N=4184) | 1500 / 12152 (1234) | 705 / 6238 (1130) | 795 / 5914 (1344) | 214 | 1.19 (1.07 – 1.32); p=0.001 | 1.19 (1.07 – 1.32); p=0.001 |
| EF >45% (N=614) | 139 / 1941 (716) | 52 / 978 (532) | 87 / 963 (903) | 371 | 1.71 (1.21 – 2.41); p=0.002 | 1.74 (1.23 – 2.45); p=0.002 |
| EF <35% (N=2963) | 1164 / 8417 (1383) | 558 / 4328 (1289) | 606 / 4090 (1482) | 192 | 1.15 (1.02 – 1.29); p=0.019 | 1.14 (1.02–1.28); p=0.027 |
| EF 35–55% (N=1585) | 416 / 4879 (853) | 181 / 2485 (728) | 235 / 2395 (981) | 253 | 1.35 (1.11 – 1.64); p=0.002 | 1.40 (1.15 – 1.70); p=0.001 |
| EF >55% (N=250) | 59 / 796 (741) | 18 / 404 (446) | 41 / 392 (1046) | 600 | 2.33 (1.34 – 4.06); p=0.002 | 2.25 (1.28 – 3.92); p=0.005 |
*
Adjusted for age, sex, race, body mass index, HF duration, HF etiology, prior myocardial infarction, current angina pectoris, hypertension, diabetes mellitus, use of digoxin (pre-trial), angiotensin-converting enzyme inhibitors, diuretics, and combination of hydralazine and nitrates, current dyspnea at rest and dyspnea on exertion, heart rate, systolic and diastolic blood pressure, current jugular venous distension, third heart sound, pulmonary râles, and lower extremity edema, NYHA functional class, pulmonary congestion and cardiothoracic ratio >0.5 by chest x-ray, serum potassium, and ejection fraction.