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Potential “cell of origin” of pancreatic ductal neoplasia in mouse models and human pancreata. Adapted and reprinted, with permission, from the Annual Review of Pathology: Mechanisms of Disease, Vol. 3, (c)2008 by Annual Reviews www.annualreviews.org(5). Vertical bars indicate the cell of origin as currently established. Backward arrows signify the remaining possibility that the PanIN precursor cell may originate in centroacinar cells.
