Table 1.

KRAS2 mutations in acinar ductal metaplasia with (Group I) or without associated PanINs (Group II)

Group		Case#	Age	Sex	Diagnosis	Stroma	Acinar cells	Metaplasia	PanIN
Group I	IA	MP1	80’s	M	Endocrine neoplasm	WT	WT	GAT	GAT
Leisons with		MP4	50’s	F	Endocrine neoplasm	WT	WT	GTT*	GTT
an associated		MP5	80’s	F	Cholangiocarcinoma	WT	WT	GAT	GAT
PanIN		MP6	60’s	F	Ampullary adenocarcinoma	WT	WT	GAT*	GAT*
		MP8	50’s	M	Chronic pancreatitis	WT	WT	GTT*	GTT
		MP9	70’s	M	Duodenal adenocarcinoma	WT	WT	GTT*	GTT*
		MP11	60’s	F	Duodenal adenocarinoma	WT	WT	GTT	GTT
		MP13	40’s	F	Endocrine neoplasm	WT	WT	GAT	GAT
		MP14	70’s	F	IPMN	WT	WT	GAT*	GAT
		MP16	40’s	F	Serous cystadenoma	WT	WT	GAT+GTT	GTT
		MP17	30’s	F	Endocrine neoplasm	WT	WT	GTT*	GTT*
		MP19	50’s	M	Endocrine neoplasm	WT	WT	GTT*	GTT
	IB	MP3	60’s	M	Ductal adenocarcinoma	WT	WT	WT	GTT*
		MP15	60’s	F	Ductal adenocarcinoma	WT	WT	WT	CGT
	IC	MP2	80’s	M	Ductal adenocarcinoma	WT	WT	WT	WT
		MP7	60’s	F	Ampullary adenocarcinoma	WT	WT	WT	WT
		MP10	60’s	F	Ampullary adenocarcinoma	WT	WT	WT	WT
		MP12	60’s	M	Serous cystadenoma	WT	WT	WT	WT
		MP18	60’s	M	Ampullary adenocarcinoma	WT	WT	WT	WT
Group II		M1	60’s	M	Chronic pancreatitis	WT	WT	WT
Lesions		M2	60’s	M	Ductal adenocarcinoma	WT	WT	WT
without		M3	50’s	M	Serous cystadenoma	WT	WT	WT
an associated		M4	50’s	M	Chronic pancreatitis	WT	WT	WT
PanIN		M5	60’s	M	Chronic pancreatitis	WT	WT	WT
		M6	60’s	M	Chronic pancreatitis	WT	WT	WT
		M7	60’s	M	Chronic pancreatitis	WT	WT	WT
		M8	70’s	M	Serous cystadenoma	WT	WT	WT
		M9	50’s	F	Serous cystadenoma	WT	WT	WT
		M10	30’s	F	Endocrine neoplasm	WT	WT	WT
		M11	60’s	M	Ampullary adenocarcinoma	WT	WT	WT
		M12	60’s	M	IPMN	WT	WT	WT

Case numbers and mutations are shown in bold. WT: wild type GGT codons. Age is provided as decades of life to maintain patient privacy.

Asterisk indicates cases that were wildtype by DNA sequencing, but where a mutation was found using LigAmp.