G2/M delay |
G2/M delay in Mcm4C/C MEFs and developmental lethality in Mcm4C
/Δ mice |
Translocation and segmental deletion or amplification at LTR sites. |
Embryonic fibroblasts highly susceptible to chromosome breaks under replication stress |
100-fold increase in mitotic recombination |
20-fold increase in frequency of micronuclei in erythrocytes, likely representative of elevated DSBs |
Predisposition to improved growth |
80% of females acquire aggressive mammary tumors |
Particular chromosome abnormalities in individual improved growth strains |
Different segmental aneuploidies in independent tumor cell lines (detected by array CGH; unpublished results) |