Skip to main content
. 2009 Jul 28;7(7):e1000161. doi: 10.1371/journal.pbio.1000161

Table 1. Phenotypic similarities between mcm4Chaos3 yeast and Mcm4Chaos3 mice.

Yeast Micea
G2/M delay G2/M delay in Mcm4C/C MEFs and developmental lethality in Mcm4C mice
Translocation and segmental deletion or amplification at LTR sites. Embryonic fibroblasts highly susceptible to chromosome breaks under replication stress
100-fold increase in mitotic recombination 20-fold increase in frequency of micronuclei in erythrocytes, likely representative of elevated DSBs
Predisposition to improved growth 80% of females acquire aggressive mammary tumors
Particular chromosome abnormalities in individual improved growth strains Different segmental aneuploidies in independent tumor cell lines (detected by array CGH; unpublished results)
a

See [6],[41].