Table 3.
Most significantly dysregulated genes (> 4-fold change in 100% of all cases) in intrahepatic cholangiocarcinoma - relation to known cellular functions and metabolic pathways (using the GenMAPP® software)
| Swiss prot | GenMAPP ID | Gene ID | Dysregulated in % | Name | fc inc (median) | fc dec (median) |
| Cell adhesion (cell-cell/cell-matrix)-extracellular matrix | ||||||
| OSTP_HUMAN | P10451 | SPP1 | 100 | Osteopontin precursor (Bone sialoprotein 1/SPP-1 1) | 33.5 | |
| Q13443 | Q13443 | ADAM9 | 100 | A disintegrin and metalloproteinase domain 9 (meltrin γ) | 10.4 | |
| TYBO_HUMAN | P13472 | TMSB10 | 100 | Thymosin beta-10 | 5.3 | |
| ITA6_HUMAN | P23229 | ITGA6 | 100 | Integrin alpha-6 precursor | 4.5 | |
| Signal transduction - G protein signaling | ||||||
| CD24_HUMAN | P25063 | CD24 | 100 | Signal transducer CD24 precursor | 11.8 | |
| IQG1_HUMAN | P46940 | IQGAP1 | 100 | Ras GTPase-activating-like protein IQGAP1 | 9.1 | |
| ECT2_HUMAN | Q9H8V3 | ECT2 | 100 | ECT2 protein (Epithelial cell transforming 2 oncogene) | 6.3 | |
| MACS_HUMAN | P29966 | MACS | 100 | Myristolated alanine-rich C-kinase substrate (MARCKS) | 4.6 | |
| Q9BUV5 | Q9BUV5 | INSIG1 | 100 | Similar to insulin induced gene 1 | 5 | |
| Cell cycle - DNA replication | ||||||
| RIR2_HUMAN | P31350 | RRM2 | 100 | Ribonucleoside-diphosphate reductase M2 chain | 16.2 | |
| S111_HUMAN | P31949 | S100A11 | 100 | Calgizzarin (S100C protein) | 15.5 | |
| O00496 | O00496 | IPL | 100 | Tumor suppressing subtransferable candidate 3 | 14.1 | |
| S106_HUMAN | P06703 | S100A6 | 100 | Calcyclin (Growth factor inducible protein 2A9) | 6.9 | |
| Transcription | ||||||
| SOX9_HUMAN | P48436 | SOX9 | 100 | Transcription factor SOX9 | 4.1 | |
| NRI3_HUMAN | Q14994 | NR1/3 | 100 | Orphan nuclear receptor NR1/3 | 6.8 | |
| Cell motility – cytoskeleton | ||||||
| SPT2_HUMAN | O53291 | SPINT2 | 100 | Kunitz-type protease inhibitor 2 precursor (Hepatocyte growth factor activator inhibitor type 2) | 5.8 | |
| Amino acid metabolism | ||||||
| BHMT_HUMAN | Q93088 | BHMT | 100 | Betaine-homocysteine S-methyltransferase | 48.5 | |
| METL_HUMAN | Q00266 | MAT1A | 100 | S-adenosylmethionine synthetase alpha and beta forms | 38.5 | |
| ATTY_HUMAN | P17735 | TAT | 100 | Tyrosine aminotransferase | 27.0 | |
| SPYA_HUMAN | P21549 | AGXT | 100 | Serine-pyruvate aminotransferase | 22.0 | |
| HUTH_HUMAN | P42357 | HAL | 100 | Histidine ammonia-lyase | 16.7 | |
| CGL_HUMAN | P32929 | CTH | 100 | Cystathione gamma-lyase (Gamma-Cystathionase) | 9.9 | |
| GLSL_HUMAN | Q9UI32 | GA | 100 | Glutaminase, liver isoform, mitochondrial precursor | 9.5 | |
| GAMT_HUMAN | Q14353 | GAMT | 100 | Guanidinoacaetate N-methyltransferase | 8.4 | |
| SDHL_HUMAN | P20132 | SDS | 100 | L-serine dehydratase | 7.1 | |
| Carbohydrate/monosaccharide metabolism/catabolism | ||||||
| KPY2_HUMAN | P14786 | PKM2 | 100 | Pyruvate kinase, M2 isozyme | 26.7 | |
| ALFA_HUMAN | P04075 | ALDOA | 100 | Fructose biphosphate aldolase A (Lung cancer antigen) | 16.3 | |
| PPCC_HUMAN | Q16822 | PCK1 | 100 | Phosphoenolpyruvate carboxykinase, cytosolic | 16.7 | |
| Q9H277 | Q9H277 | Q9H227 | 100 | Cytosolic beta-glucosidase | 7.6 | |
| Electron transport | ||||||
| ACDB_HUMAN | P45954 | ACADSB | 100 | Acyl-CoA dehydrogenase, branched chain specific | 14.1 | |
| CPA6_HUMAN | X13929 | CYP2A6 | 100 | Cytochrome P450 2A6 | 11.9 | |
| CP12_HUMAN | P05177 | CYP1A2 | 100 | Cytochrome P450 1A2 | 10.0 | |
| Protein metabolism/proteolysis | ||||||
| BAE2_HUMAN | Q9Y5Z0 | BACE2 | 100 | Beta secretase 2 precursor | 10.5 | |
| Q9UJ28 | Q9UJ28 | GALNT7 | 100 | UDP-GalNAc: N-acetylgalactosaminyltransferase 7 | 5.4 | |
| CATC_HUMAN | P53634 | CTSC | 100 | Dipeptidyl-peptidase I precursor | 4.7 | |
| GLMT_HUMAN | Q14749 | GNMT | 100 | Glycine N-methyltransferase | 49.5 | |
| Transport | ||||||
| CHLR_HUMAN | P17516 | AKR1C4 | 100 | Chlordecone reductase | 22.0 | |
| APF_HUMAN | Q13790 | APOF | 100 | Apolipoprotein F precursor | 15.5 | |
| Lipid binding/metabolism | ||||||
| Q9Y2P5 | Q9Y2P5 | Q9Y2P5 | 100 | Very-long-chain AcylCoA synthetase homolog 2 | 23.7 | |
| VLCS_HUMAN | O14975 | FACVL1 | 100 | Very-long-chain AcylCoA synthetase | 16.6 | |
| MMSA_HUMAN | Q02252 | MMSDH | 100 | Methylmalonate-semialdehyde dehydrogenase | 8.1 | |