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. 2009 May 6;47(7):2084–2089. doi: 10.1128/JCM.02159-08

TABLE 1.

Clinical and epidemiological details and results of serological tests and Q-PCR assays of 17 chronic brucellosis patients upon entry into the study

Patient no. Dates of sample collection Age (yr)/sexa Yr of infection Focal complication Associated diseaseb Clinical manifestation(s) Result by the following testc:
Treatment (days)d Outcome
RB STA Coombs Q-PCR
Blood Serum
Group A (focal-disease patients)
    1 Apr. 2005-Feb. 2009 66/M 1998 Spleen abscess Diabetes Polyarthralgia + 1,280 5,120 6 0 1, Dox (60) + Strep (15); 2, Dox (60) + Rif (60) + TMP-SMZ (60); 3, Dox (180) Polyarthralgia
    2 Aug. 2005-Jan. 2009 51/M 1978 Pain in right hip Hypertension, dyslipidemia, depression, glaucoma Pain in right hip − − 1,280 271 154 Dox (90) + Rif (90) Pain in right hip
    3 June 2006-Jan. 2009 44/M 1990 Multiple multifocal motor neuropathy Multiple multifocal motor neuropathy Loss of right-hand strength − − 40 461 0 1, Dox (240) + Rif (240); 2, Dox (180) + Rif (180) Loss of right-hand strength
    4 Sept. 2006-Oct. 2007 30/M 1998 Pain in right knee Epileptic crisis Polyarthralgia − − 40 0e 0e Dox (45) + Gent (7) Polyarthralgia
    5 Nov. 2003-Feb. 2009 35/M 1999 Sacroiliitis Hemochromatosis, obesity, seborrheic dermatitis Osteoarticular pain + 20 1,280 136 35 None recommended Polyarthralgia
    6 Mar. 2007-Jan. 2009 40/F 1993 Spondylitis L5 Fibromyalgia, asthma Arthromyalgia, lumbar pain − − 80 125 94 Dox (90) + Rif (90) Osteomuscular pain
    7 Dec. 2006-Sept. 2008 64/M 2000 Spondylitis None None + 20 640 96 0 None recommended Asymptomatic
    8 July 2003-Dec. 2008 60/M 2000 Hepatic abscess None None − − 640 72 359 None recommended Asymptomatic
Group B (nonfocal-disease patients with subjective complaints)
    9 Mar. 2003-Nov. 2008 44/M 1990 None CFS, hepatitis C Osteomuscular pain − − − 178 132 None recommended Osteomuscular pain
    10 Feb. 2003-Jan. 2008 57/M 1997 None Prostatitis Polyarthralgia − − 1,280 6 0 1, Dox (60); 2, Dox (60); 3, Dox (60); 4, Dox (60) Polyarthralgia
    11 Jan. 2006-Feb. 2009 49/F 2006 None CFS, DM II Polyarthralgia, asthenia + 80 320 3,755 0 1, Dox (60); 2, Dox (45) + Strep (14); 3, TMP-SMZ (90); 4, Dox (90) Polyarthralgia
    12 Dec. 2002-Feb. 2009 54/M 2002 None Schizophrenia Pain in right shoulder + 40 20,480 0 797 None recommended Asymptomatic
    13 Apr. 2003-Feb. 2009 42/F 1994 None CFS Polyarthralgia, fatigue, asthenia − 40 40 112 0 Dox (180) Osteomuscular pain
    14 June 2006-Jan. 2009 36/F 1996 None None Polyarthralgia + 80 2,560 0 182 1, Dox + Rif (interrupted); 2, TMP-SMZ (90); 3, Dox (90) Polyarthralgia
    15 July 2006-Oct. 2008 35/M 1997 None Hyperlipidemia Polyarthralgia − − − 32 366 Dox (120) + Rif (120) Polyarthralgia
    16 Oct. 2007-Jan. 2009 37/M 1991 None CFS Polyarthralgia − − − 0 121 None recommended Polyarthralgia
    17 Feb. 2008-Jan. 2009 56/M 1975 None CFS, hypothyroidism, hypertension Polyarthralgia − 40 2,560 25 0 Rif (interrupted) Polyarthralgia
a

M, male; F, female.

b

DM II, diabetes mellitus type II.

c

RB, rose bengal; STA, standard tube agglutination; +, positive; −, negative. Standard tube agglutination and Coombs test results are expressed as reciprocal serology titers. Q-PCR results are expressed as copies of B. melitensis DNA per milliliter of sample.

d

Dox, doxycycline (100 mg/12 h); Strep, streptomycin (1 g/24 h); Rif, rifampin (900 mg/24 h); Gent, gentamicin (240 mg/24 h); TMP-SMZ, cotrimoxazole (trimethoprim [TMP], 160 mg/12 h; sulfamethoxazole [SMZ], 800 mg/12 h). Numbers followed by commas indicate the first, second, third, or fourth course of treatment.

e

Upon entry into the study, the SF sample was positive by the Q-PCR assay, with 175 copies/ml.