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. 2009 Jun 3;110(2):426–441. doi: 10.1093/toxsci/kfp116

FIG. 9.

FIG. 9.

Enhancement of TCDD toxicity by AHRR knockdown as determined by severity of pericardial edema. Assessment of TCDD-induced pericardial edema for the various AHRR MO treatments are assumed to be the same as the average increase in PSS from TCDD-exposed embryos microinjected with Ctrl MO. Assessments of TCDD-induced pericardial edema in noninjected embryos (No MO) were based on comparison to control embryos (noninjected and DMSO treated). MO-induced changes in PSS were determined from DMSO-treated embryos. The sum of these two causative factors (MO and TCDD treatment) was used to determine the magnitude of TCDD-induced edema that is specifically enhanced (i.e., more than additive) as a result of AHRR knockdown. AHRRa knockdown alone resulted in significant pericardial edema that was further enhanced by TCDD exposure. In contrast, AHRRb knockdown alone caused minimal pericardial edema in control embryos but significantly enhanced the TCDD-induced pericardial edema.