FIG. 6.
Concentration-dependent efficacy of GSK501015 in HIV-infected hCD4/hCCR5 transgenic rats. These analyses contain results obtained from both the high-dose and the dose titration studies. (A) Number of HIV-1 integrants per ng DNA determined in the spleen versus the day 1 maximum concentration of GSK501015 (Cmax) in serum. The dotted curve indicates the fit of the Hill curve. (B) Levels of episomal two-LTR circles relative to the administered GSK501015 dose. The gray boxes indicate the geometric means of two-LTR circles in samples from the untreated control groups and the group treated at 10 mg/kg (P = 0.0172). The dotted line indicates the fitted linear relationship between log(two-LTR circles) and log dose.