FIG. 7.

In vivo relationship of HIV-1 integrants and two-LTR circles in a secondary lymphoid organ of GSK501015-treated rats. Data obtained from the two in vivo studies for levels of integrants and two-LTR circles in untreated or GSK501015-treated hCD4/hCCR5 transgenic rats are given (and also presented in part in Fig. 4 and 6). Each circle depicts the result for these two virological parameters for one HIV-infected rat (open circles, high-dose study; filled circles, dose titration study). The fitted line illustrates the inverse correlation determined by Pearson's correlation coefficient between log(integrants) and log(two-LTR circles).