Skip to main content
. 2009 May 20;83(15):7706–7717. doi: 10.1128/JVI.00683-09

TABLE 2.

Potencies of strand transfer INI GSK501015 against recombinant HIV-1 IN in vitro and against HIV-1 in antiviral assays on human cells

Integrase inhibitor Integrase IC50 (nM)a
Antiviral EC50 (nM)a
Strand transfer 3H-INI binding PBMC MT-4
GSK501015 6 (4.6, 7.9) 19.3 (9.3, 40) 2.7 (1.7, 4.3) 12.4 (9.8, 16)
Raltegravir 7.4 (4.1, 13) 6.5 (3.2, 14) 1.9 (1.3, 2.7) 4.7 (2.5, 9.0)
a

In vitro recombinant HIV IN strand transfer activity, 3H-INI binding, and antiviral HIV activity in cell-based assays were measured as reported previously (5, 14, 25). The values are geometric means, with 95% CI in parentheses, calculated from at least seven determinations.