TABLE 3.
Comparable anti-HIV-1 efficacies of INI GSK501015 in cultured primary cells from hCD4/hCCR5 transgenic rats and humans
| Species | Antiviral EC50 (nM)a
|
|
|---|---|---|
| Macrophages | T cells | |
| Rat | 7 ± 3 (n = 2) | 1 ± 0.05 (n = 3) |
| Human | 2 ± 0.5 (n = 2) | 2 ± 1 (n = 4) |
a
EC50 values were derived from the dose-response experiments shown in Fig. 1B to E and from experiments conducted in an analogous manner. Shown are the arithmetic means ± standard errors of the mean from primary cell cultures established from two to four donors; each experiment was performed in triplicate.